ENZYME entry: EC 3.4.17.11
| Accepted Name |
|---|
| Glutamate carboxypeptidase.
|
| Alternative Name(s) |
|---|
| Carboxypeptidase G. |
| Carboxypeptidase G1. |
| Carboxypeptidase G2. |
| Reaction catalysed |
|---|
| Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.
- Its ability to hydrolyze pteroyl-L-glutamate (folic acid) has led to
its use as a folate-depleting, antitumor agent.
- Belongs to peptidase family M20A.
|
| Cross-references |
|---|
| PROSITE | PDOC00613 |
| BRENDA | 3.4.17.11 |
| EC2PDB | 3.4.17.11 |
| ExplorEnz | 3.4.17.11 |
| PRIAM enzyme-specific profiles | 3.4.17.11 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.17.11 |
| IUBMB Enzyme Nomenclature | 3.4.17.11 |
| IntEnz | 3.4.17.11 |
| MEDLINE | Find literature relating to 3.4.17.11 |
| MetaCyc | 3.4.17.11 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-