ENZYME entry: EC 3.4.17.11

Accepted Name
Glutamate carboxypeptidase.
Alternative Name(s)
Carboxypeptidase G.
Carboxypeptidase G1.
Carboxypeptidase G2.
Reaction catalysed
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups
Cofactor(s)
Zn(2+).
Comment(s)
  • Produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.
  • Its ability to hydrolyze pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumor agent.
  • Belongs to peptidase family M20A.
Cross-references
PROSITEPDOC00613
BRENDA3.4.17.11
EC2PDB3.4.17.11
ExplorEnz3.4.17.11
PRIAM enzyme-specific profiles3.4.17.11
KEGG Ligand Database for Enzyme Nomenclature3.4.17.11
IUBMB Enzyme Nomenclature3.4.17.11
IntEnz3.4.17.11
MEDLINEFind literature relating to 3.4.17.11
MetaCyc3.4.17.11
UniProtKB/Swiss-Prot
P06621, CBPG_PSES6

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