ENZYME entry: EC 3.4.17.13

Accepted Name
Muramoyltetrapeptide carboxypeptidase.
Alternative Name(s)
Carboxypeptidase IIW.
Reaction catalysed
GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O <=> GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine
Comment(s)
  • Variants are known from various microorganisms.
  • Involved in peptidoglycan synthesis, catalyzing both decarboxylation and transpeptidation.
  • Stimulated by divalent cations such as magnesium and calcium, but not zinc.
  • Inhibited by thiol-blocking reagents, but unaffected by penicillin.
Cross-references
BRENDA3.4.17.13
EC2PDB3.4.17.13
ExplorEnz3.4.17.13
PRIAM enzyme-specific profiles3.4.17.13
KEGG Ligand Database for Enzyme Nomenclature3.4.17.13
IUBMB Enzyme Nomenclature3.4.17.13
IntEnz3.4.17.13
MEDLINEFind literature relating to 3.4.17.13
MetaCyc3.4.17.13
UniProtKB/Swiss-Prot
Q8XDJ8, LDCA_ECO57;  P59238, LDCA_ECOL6;  P76008, LDCA_ECOLI;  
Q9HTZ1, LDC_PSEAE;  P0AFV6, MEPS_ECO57;  P0AFV5, MEPS_ECOL6;  
P0AFV4, MEPS_ECOLI;  P0AFV7, MEPS_SHIFL;  Q9VYX7, PGPSA_DROME;  

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