ENZYME entry: EC 3.4.17.20

Accepted Name
Carboxypeptidase U.
Alternative Name(s)
Arginine carboxypeptidase.
Carboxypeptidase B2.
Carboxypeptidase R.
Plasma carboxypeptidase B.
TAFI.
Thrombin-activatable fibrinolysis inhibitor.
Reaction catalysed
Release of C-terminal Arg and Lys from a polypeptide
Cofactor(s)
Zn(2+).
Comment(s)
  • Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
  • Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg.
  • Belongs to peptidase family M14.
Cross-references
BRENDA3.4.17.20
EC2PDB3.4.17.20
ExplorEnz3.4.17.20
PRIAM enzyme-specific profiles3.4.17.20
KEGG Ligand Database for Enzyme Nomenclature3.4.17.20
IUBMB Enzyme Nomenclature3.4.17.20
IntEnz3.4.17.20
MEDLINEFind literature relating to 3.4.17.20
MetaCyc3.4.17.20
UniProtKB/Swiss-Prot
Q2KIG3, CBPB2_BOVIN;  Q96IY4, CBPB2_HUMAN;  Q9JHH6, CBPB2_MOUSE;  
Q9EQV9, CBPB2_RAT;  

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