ENZYME entry: EC 3.4.17.21

Accepted Name
Glutamate carboxypeptidase II.
Alternative Name(s)
Folate hydrolase.
N-acetylated-gamma-linked-acidic dipeptidase.
NAALADase.
Pteroylpoly-gamma-glutamate carboxypeptidase.
Reaction catalysed
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates
Cofactor(s)
Zinc.
Comment(s)
  • Hydrolyzes alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu and folylpoly-gamma- glutamates.
  • With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate.
  • Does not hydrolyze Ac-beta-Asp-Glu.
  • Inhibited by quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl- pentanedioate.
  • The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalyzed by EC 3.4.17.11 and EC 3.4.19.9.
  • Belongs to peptidase family M28.
  • Formerly EC 3.4.19.8.
Cross-references
BRENDA3.4.17.21
EC2PDB3.4.17.21
ExplorEnz3.4.17.21
PRIAM enzyme-specific profiles3.4.17.21
KEGG Ligand Database for Enzyme Nomenclature3.4.17.21
IUBMB Enzyme Nomenclature3.4.17.21
IntEnz3.4.17.21
MEDLINEFind literature relating to 3.4.17.21
MetaCyc3.4.17.21
UniProtKB/Swiss-Prot
Q04609, FOLH1_HUMAN;  O35409, FOLH1_MOUSE;  O77564, FOLH1_PIG;  
P70627, FOLH1_RAT;  Q9M1S8, GCP2_ARATH;  Q5WN23, GCP2_CAEBR;  
P91406, GCP2_CAEEL;  Q9Y3Q0, NALD2_HUMAN;  Q9CZR2, NALD2_MOUSE;  
Q9UQQ1, NALDL_HUMAN;  Q7M758, NALDL_MOUSE;  O54697, NALDL_RAT;  

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