ID   3.4.17.21
DE   glutamate carboxypeptidase II.
AN   folate hydrolase.
AN   NAALADase.
AN   N-acetylated-gamma-linked-acidic dipeptidase.
AN   pteroylpoly-gamma-glutamate carboxypeptidase.
CA   Release of an unsubstituted, C-terminal glutamyl residue, typically from
CA   Ac-Asp-Glu or folylpoly-gamma-glutamates.
CC   -!- Hydrolyzes alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu,
CC       but also gamma-glutamyl bonds in gamma-Glu-Glu and folylpoly-gamma-
CC       glutamates.
CC   -!- With folylpoly-gamma-glutamates, shows processive carboxypeptidase
CC       activity to produce pteroylmonoglutamate.
CC   -!- Does not hydrolyze Ac-beta-Asp-Glu.
CC   -!- Inhibited by quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl-
CC       pentanedioate.
CC   -!- The release of C-terminal glutamate from folylpoly-gamma-glutamates
CC       is also catalyzed by EC 3.4.17.11 and EC 3.4.19.9.
CC   -!- Belongs to peptidase family M28.
CC   -!- Formerly EC 3.4.19.8.
DR   Q04609, FOLH1_HUMAN;  O35409, FOLH1_MOUSE;  O77564, FOLH1_PIG  ;
DR   P70627, FOLH1_RAT  ;  D4B1R0, GCP1_ARTBC ;  Q9M1S8, GCP2_ARATH ;
DR   Q5WN23, GCP2_CAEBR ;  P91406, GCP2_CAEEL ;  Q7Y228, LAMP1_ARATH;
DR   Q9Y3Q0, NALD2_HUMAN;  Q9CZR2, NALD2_MOUSE;  Q852M4, PLAT3_ORYSJ;
DR   A0A1D6L709, VP8_MAIZE  ;
//