ID   3.4.19.12
DE   Ubiquitinyl hydrolase 1.
AN   Ubiquitin C-terminal hydrolase.
AN   Ubiquitin carboxyl-terminal hydrolase.
AN   Ubiquitin thiolesterase.
CA   Thiol-dependent hydrolysis of ester, thioester, amide, peptide and
CA   isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue
CA   protein attached to proteins as an intracellular targeting signal).
CC   -!- Links to polypeptides smaller than 60 residues are hydrolyzed more
CC       readily than those to larger polypeptides.
CC   -!- Isoforms exist with quantitatively different specificities among the
CC       best known being UCH-L1 and UCH-L3, major proteins of the brain of
CC       mammals.
CC   -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by
CC       aminoacetaldehyde).
CC   -!- Belongs to peptidase family C12.
PR   PROSITE; PDOC00127;
DR   Q9M391, ATX3H_ARATH;  Q9H3M9, ATX3L_HUMAN;  Q60XN1, ATX3_CAEBR ;
DR   O17850, ATX3_CAEEL ;  Q9W689, ATX3_CHICK ;  P54252, ATX3_HUMAN ;
DR   Q9CVD2, ATX3_MOUSE ;  Q8LQ36, ATX3_ORYSJ ;  O35815, ATX3_RAT   ;
DR   A2VDM8, BAP1_BOVIN ;  C4A0D9, BAP1_BRAFL ;  Q5F3N6, BAP1_CHICK ;
DR   A1L2G3, BAP1_DANRE ;  Q92560, BAP1_HUMAN ;  Q99PU7, BAP1_MOUSE ;
DR   D3ZHS6, BAP1_RAT   ;  Q52L14, BAP1_XENLA ;  Q66JB6, BAP1_XENTR ;
DR   Q17N72, CALYP_AEDAE;  B0W2R4, CALYP_CULQU;  B3MIV9, CALYP_DROAN;
DR   B3NPV7, CALYP_DROER;  B4JW98, CALYP_DROGR;  Q7K5N4, CALYP_DROME;
DR   B4KT51, CALYP_DROMO;  B4GAM2, CALYP_DROPE;  Q291J4, CALYP_DROPS;
DR   B4HST0, CALYP_DROSE;  B4QHH0, CALYP_DROSI;  B4LQ24, CALYP_DROVI;
DR   B4P6P6, CALYP_DROYA;  A1CIL1, CREB_ASPCL ;  B0Y4P5, CREB_ASPFC ;
DR   B8NSV5, CREB_ASPFN ;  Q4WQI1, CREB_ASPFU ;  A2Q9N1, CREB_ASPNC ;
DR   Q2UUG8, CREB_ASPOR ;  Q0CT11, CREB_ASPTN ;  Q96V54, CREB_EMENI ;
DR   A1CW53, CREB_NEOFI ;  Q1RMU2, CYLD_BOVIN ;  Q9NQC7, CYLD_HUMAN ;
DR   Q80TQ2, CYLD_MOUSE ;  Q5RED8, CYLD_PONAB ;  Q66H62, CYLD_RAT   ;
DR   Q1HVH9, DEN_EBVA8  ;  P03186, DEN_EBVB9  ;  Q3KSU8, DEN_EBVG   ;
DR   P28955, DEN_EHV1B  ;  Q9E6N3, DEN_GAHVM  ;  P16785, DEN_HCMVA  ;
DR   Q6SW84, DEN_HCMVM  ;  D5LX59, DEN_HCMVT  ;  P10220, DEN_HHV11  ;
DR   P89459, DEN_HHV2H  ;  P52340, DEN_HHV6U  ;  Q9QJ37, DEN_HHV6Z  ;
DR   Q2HR64, DEN_HHV8P  ;  O41965, DEN_MHV68  ;  A8E1C4, DEN_MUHVK  ;
DR   Q6UDJ5, DEN_PSHV1  ;  P09278, DEN_VZVD   ;  Q4JQX9, DEN_VZVO   ;
DR   P55824, FAF_DROME  ;  Q5EAE5, JOS1_BOVIN ;  Q15040, JOS1_HUMAN ;
DR   Q9DBJ6, JOS1_MOUSE ;  Q5R739, JOS1_PONAB ;  Q5BJY4, JOS1_RAT   ;
DR   Q8TAC2, JOS2_HUMAN ;  Q9CR30, JOS2_MOUSE ;  O82391, JOSL_ARATH ;
DR   Q9W422, JOSL_DROME ;  Q6TQR6, L_CCHFI    ;  Q66431, L_DUGBA    ;
DR   Q9VVR1, NOT_DROME  ;  Q05B57, OTU1_BOVIN ;  Q5F3A6, OTU1_CHICK ;
DR   Q567B1, OTU1_DANRE ;  Q55BI3, OTU1_DICDI ;  Q9VRJ9, OTU1_DROME ;
DR   Q29FC9, OTU1_DROPS ;  Q5VVQ6, OTU1_HUMAN ;  Q8CB27, OTU1_MOUSE ;
DR   Q32Q05, OTU1_RAT   ;  O13974, OTU1_SCHPO ;  Q0IH43, OTU1_XENLA ;
DR   P43558, OTU1_YEAST ;  Q08BW0, OTU5A_DANRE;  Q7ZX21, OTU5A_XENLA;
DR   Q640H3, OTU5B_XENLA;  Q8TE49, OTU7A_HUMAN;  Q8R554, OTU7A_MOUSE;
DR   Q6GQQ9, OTU7B_HUMAN;  Q96FW1, OTUB1_HUMAN;  Q7TQI3, OTUB1_MOUSE;
DR   B2RYG6, OTUB1_RAT  ;  Q96DC9, OTUB2_HUMAN;  Q9CQX0, OTUB2_MOUSE;
DR   Q8LG98, OTUBL_ARATH;  A8XDJ2, OTUBL_CAEBR;  Q9XVR6, OTUBL_CAEEL;
DR   Q9VL00, OTUBL_DROME;  Q96G74, OTUD5_HUMAN;  Q3U2S4, OTUD5_MOUSE;
DR   Q2YDU3, OTUD5_RAT  ;  Q6GL44, OTUD5_XENTR;  P0C6W1, R1AB_BC133 ;
DR   P0C6V9, R1AB_BC279 ;  P0C6W0, R1AB_BC512 ;  P0C6W2, R1AB_BCHK3 ;
DR   P0C6W3, R1AB_BCHK4 ;  P0C6W4, R1AB_BCHK5 ;  P0C6W5, R1AB_BCHK9 ;
DR   P0C6W6, R1AB_BCRP3 ;  P0C6W7, R1AB_CVBEN ;  P0C6W8, R1AB_CVBLU ;
DR   P0C6W9, R1AB_CVBM  ;  P0C6X0, R1AB_CVBQ  ;  P0C6X1, R1AB_CVH22 ;
DR   P0C6X2, R1AB_CVHN1 ;  P0C6X3, R1AB_CVHN2 ;  P0C6X4, R1AB_CVHN5 ;
DR   P0C6X5, R1AB_CVHNL ;  P0C6X6, R1AB_CVHOC ;  P0C6X7, R1AB_CVHSA ;
DR   P0C6X8, R1AB_CVM2  ;  P0C6X9, R1AB_CVMA5 ;  P0C6Y0, R1AB_CVMJH ;
DR   P0C6Y5, R1AB_CVPPU ;  Q98VG9, R1AB_FIPV  ;  P0C6Y4, R1AB_PEDV7 ;
DR   P0C6F7, R1A_BC133  ;  P0C6F5, R1A_BC279  ;  P0C6F6, R1A_BC512  ;
DR   P0C6F8, R1A_BCHK3  ;  P0C6T4, R1A_BCHK4  ;  P0C6T5, R1A_BCHK5  ;
DR   P0C6T6, R1A_BCHK9  ;  P0C6T7, R1A_BCRP3  ;  P0C6T8, R1A_CVBEN  ;
DR   P0C6T9, R1A_CVBLU  ;  P0C6U0, R1A_CVBM   ;  P0C6U1, R1A_CVBQ   ;
DR   P0C6U2, R1A_CVH22  ;  P0C6U3, R1A_CVHN1  ;  P0C6U4, R1A_CVHN2  ;
DR   P0C6U5, R1A_CVHN5  ;  P0C6U6, R1A_CVHNL  ;  P0C6U7, R1A_CVHOC  ;
DR   P0C6U8, R1A_CVHSA  ;  P0C6U9, R1A_CVM2   ;  P0C6V0, R1A_CVMA5  ;
DR   P0C6V1, R1A_CVMJH  ;  P0C6V2, R1A_CVPPU  ;  P0C6V6, R1A_PEDV7  ;
DR   P19811, RPOA_EAVBU ;  Q9YN02, RPOA_PRRS1 ;  Q8B912, RPOA_PRRSB ;
DR   Q04561, RPOA_PRRSL ;  Q9WJB2, RPOA_PRRSR ;  A0MD28, RPOA_PRRSS ;
DR   P52362, TEGU_HHV7J ;  P21580, TNAP3_HUMAN;  Q4R8W3, TNAP3_MACFA;
DR   Q60769, TNAP3_MOUSE;  Q9VH90, TRBID_DROME;  Q7RTZ2, U17L1_HUMAN;
DR   Q6R6M4, U17L2_HUMAN;  Q7M764, U17L2_MOUSE;  A6NCW0, U17L3_HUMAN;
DR   A8MUK1, U17L5_HUMAN;  Q6QN14, U17L6_HUMAN;  Q2NL57, UB10A_XENLA;
DR   Q7ZXR7, UB10B_XENLA;  Q52KZ6, UB12A_XENLA;  Q5M981, UB12B_XENLA;
DR   Q6GNI6, UB22A_XENLA;  Q6DCJ1, UB22B_XENLA;  Q09444, UBH4_CAEEL ;
DR   P35127, UBL1_YEAST ;  Q10171, UBLH1_SCHPO;  Q9UUB6, UBLH2_SCHPO;
DR   Q9ZSB5, UBP10_ARATH;  A5PJS6, UBP10_BOVIN;  Q5ZJN4, UBP10_CHICK;
DR   Q14694, UBP10_HUMAN;  P52479, UBP10_MOUSE;  Q3KR59, UBP10_RAT  ;
DR   Q6DIJ4, UBP10_XENTR;  P53874, UBP10_YEAST;  Q9MAQ3, UBP11_ARATH;
DR   Q01988, UBP11_CANFA;  P51784, UBP11_HUMAN;  Q99K46, UBP11_MOUSE;
DR   Q9UUD6, UBP11_SCHPO;  P36026, UBP11_YEAST;  Q9FPT1, UBP12_ARATH;
DR   A5D9H7, UBP12_BOVIN;  A4FUN7, UBP12_DANRE;  O75317, UBP12_HUMAN;
DR   Q9D9M2, UBP12_MOUSE;  C0HB46, UBP12_SALSA;  O60079, UBP12_SCHPO;
DR   P39538, UBP12_YEAST;  Q84WU2, UBP13_ARATH;  Q92995, UBP13_HUMAN;
DR   P38187, UBP13_YEAST;  Q8L6Y1, UBP14_ARATH;  Q0IIF7, UBP14_BOVIN;
DR   Q17361, UBP14_CAEEL;  P54578, UBP14_HUMAN;  Q9JMA1, UBP14_MOUSE;
DR   P60051, UBP14_PANTR;  P40826, UBP14_RABIT;  Q11119, UBP14_SCHPO;
DR   P38237, UBP14_YEAST;  Q9FPS9, UBP15_ARATH;  Q9Y4E8, UBP15_HUMAN;
DR   Q8R5H1, UBP15_MOUSE;  P50101, UBP15_YEAST;  Q9SB51, UBP16_ARATH;
DR   Q08DA3, UBP16_BOVIN;  A8HAL1, UBP16_DANRE;  P0CAQ1, UBP16_EMENI;
DR   Q9Y5T5, UBP16_HUMAN;  Q4R6X7, UBP16_MACFA;  Q99LG0, UBP16_MOUSE;
DR   Q2KJ09, UBP16_RAT  ;  O74442, UBP16_SCHPO;  Q6PAW2, UBP16_XENLA;
DR   Q0VA64, UBP16_XENTR;  Q02863, UBP16_YEAST;  Q9FKP5, UBP17_ARATH;
DR   Q0WX57, UBP17_HUMAN;  Q67XW5, UBP18_ARATH;  Q9SJA1, UBP19_ARATH;
DR   O94966, UBP19_HUMAN;  Q3UJD6, UBP19_MOUSE;  Q6J1Y9, UBP19_RAT  ;
DR   Q9FPT5, UBP1_ARATH ;  Q29RP1, UBP1_BOVIN ;  O94782, UBP1_HUMAN ;
DR   Q8BJQ2, UBP1_MOUSE ;  Q569C3, UBP1_RAT   ;  Q9USM5, UBP1_SCHPO ;
DR   P25037, UBP1_YEAST ;  Q9FPS7, UBP20_ARATH;  A7Z056, UBP20_BOVIN;
DR   A5PN09, UBP20_DANRE;  Q9Y2K6, UBP20_HUMAN;  Q8C6M1, UBP20_MOUSE;
DR   Q5R5Z6, UBP20_PONAB;  B1WBD7, UBP20_XENLA;  A0JM59, UBP20_XENTR;
DR   Q9FIQ1, UBP21_ARATH;  Q2KJ72, UBP21_BOVIN;  Q9UK80, UBP21_HUMAN;
DR   Q9QZL6, UBP21_MOUSE;  B2GUX4, UBP21_RAT  ;  Q9UTT1, UBP21_SCHPO;
DR   Q9LEW0, UBP22_ARATH;  P0C8Z3, UBP22_BOVIN;  A6H8I0, UBP22_DANRE;
DR   Q9UPT9, UBP22_HUMAN;  Q5DU02, UBP22_MOUSE;  Q9FPS4, UBP23_ARATH;
DR   Q9FPS3, UBP24_ARATH;  Q9UPU5, UBP24_HUMAN;  B1AY13, UBP24_MOUSE;
DR   Q9FPS2, UBP25_ARATH;  Q9UHP3, UBP25_HUMAN;  P57080, UBP25_MOUSE;
DR   Q9SCJ9, UBP26_ARATH;  Q9BXU7, UBP26_HUMAN;  Q99MX1, UBP26_MOUSE;
DR   A2XDG4, UBP26_ORYSI;  A3AF13, UBP26_ORYSJ;  Q9FPS0, UBP27_ARATH;
DR   A6NNY8, UBP27_HUMAN;  Q8CEG8, UBP27_MOUSE;  Q5ZID5, UBP28_CHICK;
DR   Q96RU2, UBP28_HUMAN;  Q5I043, UBP28_MOUSE;  D3ZJ96, UBP28_RAT  ;
DR   Q9HBJ7, UBP29_HUMAN;  Q9ES63, UBP29_MOUSE;  Q8W4N3, UBP2_ARATH ;
DR   Q2KHV7, UBP2_BOVIN ;  O57429, UBP2_CHICK ;  O75604, UBP2_HUMAN ;
DR   O42726, UBP2_KLULA ;  O88623, UBP2_MOUSE ;  Q5U349, UBP2_RAT   ;
DR   Q9P3U0, UBP2_SCHPO ;  Q01476, UBP2_YEAST ;  A2BGT0, UBP30_DANRE;
DR   Q70CQ3, UBP30_HUMAN;  Q3UN04, UBP30_MOUSE;  A4QNN3, UBP30_XENTR;
DR   Q70CQ4, UBP31_HUMAN;  Q8NFA0, UBP32_HUMAN;  A6QNM7, UBP33_BOVIN;
DR   A5PMR2, UBP33_DANRE;  Q8TEY7, UBP33_HUMAN;  Q8R5K2, UBP33_MOUSE;
DR   Q5REG5, UBP33_PONAB;  Q28CN3, UBP33_XENTR;  Q70CQ2, UBP34_HUMAN;
DR   Q6ZQ93, UBP34_MOUSE;  Q9P2H5, UBP35_HUMAN;  B3M3M6, UBP36_DROAN;
DR   B3NC86, UBP36_DROER;  B4IXE0, UBP36_DROGR;  Q9VRP5, UBP36_DROME;
DR   B4KXJ5, UBP36_DROMO;  Q2LZB1, UBP36_DROPS;  B4HUI5, UBP36_DROSE;
DR   B4QIS3, UBP36_DROSI;  B4LG38, UBP36_DROVI;  B4MLR8, UBP36_DROWI;
DR   B4PIW8, UBP36_DROYA;  Q9P275, UBP36_HUMAN;  B1AQJ2, UBP36_MOUSE;
DR   F1N5V1, UBP37_BOVIN;  E2RK09, UBP37_CANFA;  E1C213, UBP37_CHICK;
DR   E7F6T8, UBP37_DANRE;  Q86T82, UBP37_HUMAN;  Q8C0R0, UBP37_MOUSE;
DR   F1SRY5, UBP37_PIG  ;  Q8NB14, UBP38_HUMAN;  Q8BW70, UBP38_MOUSE;
DR   O24454, UBP3_ARATH ;  Q9Y6I4, UBP3_HUMAN ;  Q91W36, UBP3_MOUSE ;
DR   O94269, UBP3_SCHPO ;  Q01477, UBP3_YEAST ;  Q9NVE5, UBP40_HUMAN;
DR   Q8BWR4, UBP40_MOUSE;  Q3LFD5, UBP41_HUMAN;  E1B9W9, UBP42_BOVIN;
DR   Q9H9J4, UBP42_HUMAN;  B2RQC2, UBP42_MOUSE;  D3ZU96, UBP42_RAT  ;
DR   Q70EL4, UBP43_HUMAN;  Q8BUM9, UBP43_MOUSE;  D2HBJ8, UBP44_AILME;
DR   Q7ZUM8, UBP44_DANRE;  Q9H0E7, UBP44_HUMAN;  Q0V9G5, UBP44_XENTR;
DR   Q70EL2, UBP45_HUMAN;  Q8K387, UBP45_MOUSE;  A5WWB0, UBP46_DANRE;
DR   P62068, UBP46_HUMAN;  P62069, UBP46_MOUSE;  Q5RBQ4, UBP46_PONAB;
DR   E1C1R4, UBP47_CHICK;  Q96K76, UBP47_HUMAN;  Q8BY87, UBP47_MOUSE;
DR   Q5U252, UBP47_XENLA;  A1A5G2, UBP47_XENTR;  Q5ZM45, UBP48_CHICK;
DR   Q86UV5, UBP48_HUMAN;  Q3V0C5, UBP48_MOUSE;  Q76LT8, UBP48_RAT  ;
DR   Q70CQ1, UBP49_HUMAN;  Q6P9L4, UBP49_MOUSE;  Q8LAM0, UBP4_ARATH ;
DR   Q754R5, UBP4_ASHGO ;  A6QR55, UBP4_BOVIN ;  Q6FQF0, UBP4_CANGA ;
DR   Q13107, UBP4_HUMAN ;  Q9HFS7, UBP4_KLULA ;  P35123, UBP4_MOUSE ;
DR   Q5RCD3, UBP4_PONAB ;  B2GUZ1, UBP4_RAT   ;  O60139, UBP4_SCHPO ;
DR   A7TGY3, UBP4_VANPO ;  B3LGK1, UBP4_YEAS1 ;  A6ZY34, UBP4_YEAS7 ;
DR   P32571, UBP4_YEAST ;  Q4R6D3, UBP50_MACFA;  Q6P8X6, UBP50_MOUSE;
DR   Q70EK9, UBP51_HUMAN;  O22207, UBP5_ARATH ;  P45974, UBP5_HUMAN ;
DR   P56399, UBP5_MOUSE ;  Q5R407, UBP5_PONAB ;  Q09879, UBP5_SCHPO ;
DR   P39944, UBP5_YEAST ;  Q949Y0, UBP6_ARATH ;  P35125, UBP6_HUMAN ;
DR   Q92353, UBP6_SCHPO ;  P43593, UBP6_YEAST ;  Q84WC6, UBP7_ARATH ;
DR   Q60MK8, UBP7_CAEBR ;  Q7JKC3, UBP7_CAEEL ;  Q6U7I1, UBP7_CHICK ;
DR   Q9VYQ8, UBP7_DROME ;  Q93009, UBP7_HUMAN ;  Q6A4J8, UBP7_MOUSE ;
DR   Q4VSI4, UBP7_RAT   ;  Q9P7S5, UBP7_SCHPO ;  P40453, UBP7_YEAST ;
DR   Q9C585, UBP8_ARATH ;  P40818, UBP8_HUMAN ;  Q80U87, UBP8_MOUSE ;
DR   Q09738, UBP8_SCHPO ;  P50102, UBP8_YEAST ;  Q93Y01, UBP9_ARATH ;
DR   Q9P7V9, UBP9_SCHPO ;  P39967, UBP9_YEAST ;  P54201, UBPA_DICDI ;
DR   O96612, UBPB_DICDI ;  Q24574, UBPE_DROME ;  Q5UQR3, UBPL1_MIMIV;
DR   Q5UPW7, UBPL2_MIMIV;  Q61068, UBPW_MOUSE ;  P34547, UBPX_CAEEL ;
DR   Q09931, UBPY_CAEEL ;  P23356, UCHL1_BOVIN;  Q9GM50, UCHL1_HORSE;
DR   P09936, UCHL1_HUMAN;  Q60HC8, UCHL1_MACFA;  P50103, UCHL1_MONDO;
DR   Q9R0P9, UCHL1_MOUSE;  Q6SEG5, UCHL1_PIG  ;  Q00981, UCHL1_RAT  ;
DR   Q2TBG8, UCHL3_BOVIN;  P15374, UCHL3_HUMAN;  Q9JKB1, UCHL3_MOUSE;
DR   Q06AB3, UCHL3_PIG  ;  Q91Y78, UCHL3_RAT  ;  P58321, UCHL4_MOUSE;
DR   Q9XSJ0, UCHL5_BOVIN;  Q54N38, UCHL5_DICDI;  Q9Y5K5, UCHL5_HUMAN;
DR   Q9WUP7, UCHL5_MOUSE;  Q06AT3, UCHL5_PIG  ;  O01391, UCHL_APLCA ;
DR   Q54T48, UCHL_DICDI ;  P35122, UCHL_DROME ;  Q6NTR6, UP44A_XENLA;
DR   Q5XGZ2, UP44B_XENLA;  Q93008, USP9X_HUMAN;  P70398, USP9X_MOUSE;
DR   O00507, USP9Y_HUMAN;  Q196X6, VF232_IIV3 ;  Q91FU0, VF232_IIV6 ;
DR   P22856, VL96_IRV1  ;  A6QP16, ZRAN1_BOVIN;  Q9UGI0, ZRAN1_HUMAN;
DR   Q7M760, ZRAN1_MOUSE;  B1H2Q2, ZRAN1_XENTR;  Q5U595, ZRN1A_XENLA;
DR   A0JMQ9, ZRN1B_DANRE;  Q6NUB7, ZRN1B_XENLA;
//