ID   3.4.19.13
DE   glutathione gamma-glutamate hydrolase.
AN   gamma-glutamyltranspeptidase.
AN   glutathionase.
CA   (1) glutathione + H2O = L-cysteinylglycine + L-glutamate.
CA   (2) an S-substituted glutathione + H2O = an S-substituted
CA   L-cysteinylglycine + L-glutamate.
CC   -!- This is a bifunctional protein that also has the activity of
CC       EC 2.3.2.2.
CC   -!- The enzyme binds its substrate by forming an initial gamma-glutamyl-
CC       enzyme intermediate, releasing the L-cysteinylglycine part of the
CC       molecule.
CC   -!- The enzyme then reacts with either a water molecule or a different
CC       acceptor substrate (usually an L-amino acid or a dipeptide) to form
CC       L-glutamate or a product containing a new gamma-glutamyl isopeptide
CC       bond, respectively.
CC   -!- The enzyme acts on glutathione, glutathione-S-conjugates, and, at a
CC       lower level, on other substrates with an N-terminal L-gamma-glutamyl
CC       residue.
CC   -!- It plays a crucial part in the glutathione-mediated xenobiotic
CC       detoxification pathway.
CC   -!- The enzyme consists of two chains that are created by the proteolytic
CC       cleavage of a single precursor polypeptide.
DR   Q05902, ECM38_YEAST;  Q8VYW6, GAGT1_ARATH;  Q680I5, GAGT2_ARATH;
DR   Q9M0G0, GAGT3_ARATH;  D4B387, GGT1_ARTBC ;  P19440, GGT1_HUMAN ;
DR   Q60928, GGT1_MOUSE ;  P20735, GGT1_PIG   ;  P07314, GGT1_RAT   ;
DR   Q9US04, GGT1_SCHPO ;  O14194, GGT2_SCHPO ;  A6NGU5, GGT3_HUMAN ;
DR   P36269, GGT5_HUMAN ;  Q9Z2A9, GGT5_MOUSE ;  Q9QWE9, GGT5_RAT   ;
DR   A7YWM1, GGT6_BOVIN ;  Q6P531, GGT6_HUMAN ;  Q6PDE7, GGT6_MOUSE ;
DR   Q6IE08, GGT6_RAT   ;  Q0V8L2, GGT7_BOVIN ;  Q9UJ14, GGT7_HUMAN ;
DR   Q99JP7, GGT7_MOUSE ;  Q99MZ4, GGT7_RAT   ;  P63186, GGT_BACNA  ;
DR   P54422, GGT_BACSU  ;  P18956, GGT_ECOLI  ;  Q9I406, GGT_PSEAE  ;
DR   P36267, GGT_PSEUA  ;  P74181, GGT_SYNY3  ;  P15557, PAC1_PSES3 ;
DR   Q05053, PAC1_PSESV ;  B8NM71, USTH_ASPFN ;  O05218, YWRD_BACSU ;
//