ID 3.4.19.15 DE desampylase. AN SAMP-protein conjugate cleaving protease. CA an N(6)-[small archaeal modifier protein]-[protein]-L-lysine + H2O = CA a [protein]-L-lysine + a [small archaeal modifier protein]. CC -!- The enzyme, characterized from the archaeon Haloferax volcanii, CC specifically cleaves the ubiquitin-like small modifier proteins SAMP1 CC and SAMP2 from protein conjugates, hydrolyzing the isopeptide bond CC between a lysine residue of the target protein and the C-terminal CC glycine of the modifier protein. cf. EC 3.4.19.12. CC -!- Belongs to peptidase family M67. CC -!- Formerly EC 3.4.24.88. DR D4GTS4, JAMM1_HALVD; Q8U1Y4, JAMM1_PYRFU; //