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ENZYME

ENZYME entry: EC 3.4.19.16

Accepted Name
glucosinolate gamma-glutamyl hydrolase
Reaction catalysed
  • an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate
  • (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate
  • 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate
  • (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate
Comment(s)
  • This enzyme, characterized from the plant Arabidopsis thaliana, participates in the biosynthesis of the plant defense compounds glucosinolates and camalexin.
  • It is the only known plant enzyme capable of hydrolyzing the gamma- glutamyl residue of glutathione in the cytosol.
Cross-references
BRENDA3.4.19.16
EC2PDB3.4.19.16
ExplorEnz3.4.19.16
PRIAM enzyme-specific profiles3.4.19.16
KEGG Ligand Database for Enzyme Nomenclature3.4.19.16
IUBMB Enzyme Nomenclature3.4.19.16
IntEnz3.4.19.16
MEDLINEFind literature relating to 3.4.19.16
MetaCyc3.4.19.16
Rhea expert-curated reactions3.4.19.16
UniProtKB/Swiss-Prot
Q9M0A7, GGP1_ARATHQ9M0A6, GGP2_ARATHQ9M0A5, GGP3_ARATH

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