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ENZYME entry: EC 3.4.19.2

Accepted Name
Peptidyl-glycinamidase.
Alternative Name(s)
Carboxyamidase.
Peptidyl carboxyamidase.
Reaction catalysed
Cleavage of C-terminal glycinamide from polypeptides
Comment(s)
  • Inactivates vasopressin and oxytocin by splitting off glycinamide.
  • Also cleaves ester substrates of trypsin and chymotrypsin.
  • Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide.
  • The toad skin enzyme is inhibited by diisopropyl fluorophosphate.
  • Formerly EC 3.4.15.2.
Cross-references
BRENDA3.4.19.2
EC2PDB3.4.19.2
ExplorEnz3.4.19.2
PRIAM enzyme-specific profiles3.4.19.2
KEGG Ligand Database for Enzyme Nomenclature3.4.19.2
IUBMB Enzyme Nomenclature3.4.19.2
IntEnz3.4.19.2
MEDLINEFind literature relating to 3.4.19.2
MetaCyc3.4.19.2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-