To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 3.4.19.3

Accepted Name
Pyroglutamyl-peptidase I.
Alternative Name(s)
5-oxoprolyl-peptidase.
PYRase.
Pyroglutamyl aminopeptidase.
Pyrrolidone carboxyl peptidase.
Pyrrolidone-carboxylate peptidase.
Reaction catalysed
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Comment(s)
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
Cross-references
PROSITEPDOC01036
BRENDA3.4.19.3
EC2PDB3.4.19.3
ExplorEnz3.4.19.3
PRIAM enzyme-specific profiles3.4.19.3
KEGG Ligand Database for Enzyme Nomenclature3.4.19.3
IUBMB Enzyme Nomenclature3.4.19.3
IntEnz3.4.19.3
MEDLINEFind literature relating to 3.4.19.3
MetaCyc3.4.19.3
UniProtKB/Swiss-Prot
Q8RBX8, PCP1_CALS4;  Q7MAZ1, PCP1_PHOLL;  Q8XXE9, PCP1_RALSO;  
P65678, PCP1_STRPN;  P65679, PCP1_STRR6;  P58201, PCP1_SULSO;  
Q8R9J6, PCP2_CALS4;  Q7MZ76, PCP2_PHOLL;  Q8XT56, PCP2_RALSO;  
Q97NG9, PCP2_STRPN;  P58202, PCP2_SULSO;  A8MJA9, PCP_ALKOO;  
C3P0R7, PCP_BACAA;  C3LDV2, PCP_BACAC;  A0RFP3, PCP_BACAH;  
P46107, PCP_BACAM;  Q81NT5, PCP_BACAN;  B7JDC3, PCP_BACC0;  
Q735N6, PCP_BACC1;  B7IMH6, PCP_BACC2;  C1F026, PCP_BACC3;  
B7H8H3, PCP_BACC4;  B7HVU3, PCP_BACC7;  A7GQB6, PCP_BACCN;  
B9J587, PCP_BACCQ;  Q81BT3, PCP_BACCR;  Q639M5, PCP_BACCZ;  
Q9K6U4, PCP_BACHD;  Q6HH08, PCP_BACHK;  Q65FR5, PCP_BACLD;  
P28618, PCP_BACSU;  A7Z119, PCP_BACVZ;  A9VKA7, PCP_BACWK;  
C0QXM0, PCP_BRAHW;  C0ZCX0, PCP_BREBN;  Q7NT84, PCP_CHRVO;  
A8AJA6, PCP_CITK8;  A5CM68, PCP_CLAM3;  B2UZU4, PCP_CLOBA;  
B2TK93, PCP_CLOBB;  Q0TQH4, PCP_CLOP1;  Q8XKH1, PCP_CLOPE;  
Q0ST25, PCP_CLOPS;  B5Y5X6, PCP_COPPD;  Q0KFE0, PCP_CUPNH;  
Q477F9, PCP_CUPNJ;  B2AG45, PCP_CUPTR;  Q9RX25, PCP_DEIRA;  
A4W870, PCP_ENT38;  Q838N8, PCP_ENTFA;  B2VBP1, PCP_ERWT9;  
B7LKQ5, PCP_ESCF3;  B0S415, PCP_FINM2;  Q8RI83, PCP_FUSNN;  
Q7NHX6, PCP_GLOVI;  B5XZE0, PCP_KLEP3;  Q5FMJ2, PCP_LACAC;  
Q03P20, PCP_LACBA;  B3W7M8, PCP_LACCB;  Q040L6, PCP_LACGA;  
A8YX24, PCP_LACH4;  Q74HE9, PCP_LACJO;  O87765, PCP_LACLM;  
Q03CK3, PCP_LACP3;  B1HUY7, PCP_LYSSC;  P0A5R5, PCP_MYCBO;  
A1KFE2, PCP_MYCBP;  C1AJZ7, PCP_MYCBT;  B2HP18, PCP_MYCMM;  
A5TZ46, PCP_MYCTA;  P9WIJ4, PCP_MYCTO;  P9WIJ5, PCP_MYCTU;  
Q8ENE4, PCP_OCEIH;  Q6D7H1, PCP_PECAS;  C6DCC7, PCP_PECCP;  
Q186N3, PCP_PEPD6;  P42673, PCP_PSEFL;  C3JZR3, PCP_PSEFS;  
Q9UYQ9, PCP_PYRAB;  O73944, PCP_PYRFU;  O58321, PCP_PYRHO;  
A7X782, PCP_STAA1;  A6U575, PCP_STAA2;  Q2FDH1, PCP_STAA3;  
Q2FUS6, PCP_STAA8;  A5IWB7, PCP_STAA9;  Q2YZA2, PCP_STAAB;  
Q5HCK7, PCP_STAAC;  A6QKH8, PCP_STAAE;  P65676, PCP_STAAM;  
P65677, PCP_STAAN;  Q6GDB4, PCP_STAAR;  Q6G5Y4, PCP_STAAS;  
A8Z5J1, PCP_STAAT;  Q53596, PCP_STAAU;  Q8NUH2, PCP_STAAW;  
B9DND6, PCP_STACT;  Q4L9S3, PCP_STAHJ;  Q4A002, PCP_STAS1;  
Q9RL48, PCP_STRCO;  P68896, PCP_STRP1;  Q04L55, PCP_STRP2;  
P0DC94, PCP_STRP3;  Q5XDD4, PCP_STRP6;  C1C6J3, PCP_STRP7;  
Q8P243, PCP_STRP8;  Q1JD20, PCP_STRPB;  Q1JMZ5, PCP_STRPC;  
Q1JI40, PCP_STRPD;  Q1J7Y1, PCP_STRPF;  A2RFZ5, PCP_STRPG;  
B1IB28, PCP_STRPI;  Q48UT7, PCP_STRPM;  P0DC95, PCP_STRPQ;  
B5XK96, PCP_STRPZ;  A4W0R4, PCP_STRS2;  A4VUH1, PCP_STRSY;  
C3N2L8, PCP_SULIA;  C4KEG7, PCP_SULIK;  C3MP49, PCP_SULIL;  
C3NL04, PCP_SULIN;  C3NAL6, PCP_SULIY;  B7IEE2, PCP_THEAB;  
Q5JEL5, PCP_THEKO;  O07883, PCP_THELN;  A6LL24, PCP_THEM4;  
B6YUJ5, PCP_THEON;  B0K8Z7, PCP_THEP3;  B0K0D9, PCP_THEPX;  
Q73RB6, PCP_TREDE;  A7N3R7, PCP_VIBCB;  Q5E531, PCP_VIBF1;  
B5FEA5, PCP_VIBFM;  Q87IL9, PCP_VIBPA;  Q8D4N5, PCP_VIBVU;  
Q7MG84, PCP_VIBVY;  A1JR34, PCP_YERE8;  A7FFS3, PCP_YERP3;  
Q1C571, PCP_YERPA;  B2KA64, PCP_YERPB;  Q8ZD86, PCP_YERPE;  
A9R3Y5, PCP_YERPG;  Q1CKF9, PCP_YERPN;  A4TKZ3, PCP_YERPP;  
Q667T6, PCP_YERPS;  B1JRB0, PCP_YERPY;  Q9NXJ5, PGPI_HUMAN;  
Q9ESW8, PGPI_MOUSE;  Q76IC5, PGPI_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-