ID 3.4.19.6 DE pyroglutamyl-peptidase II. AN PAP-II. AN pyroglutamyl aminopeptidase II. AN thyroliberinase. AN thyrotropin-releasing hormone degrading ectoenzyme. AN TRH-DE. AN TRH-degrading ectoenzyme. AN TRH-specific aminopeptidase. CA Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa CA tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides. CC -!- Highly specific for thyrotropin releasing hormone (pyroglutamyl- CC histidyl-prolylamide). CC -!- Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone CC releasing hormone. CC -!- Found in serum and brain. CC -!- Inhibited by metal chelators. CC -!- Belongs to peptidase family M1. DR Q9UKU6, TRHDE_HUMAN; Q8K093, TRHDE_MOUSE; Q10836, TRHDE_RAT ; //