ID 3.4.21.100 DE sedolisin. AN pseudomonalisin. AN pseudomonapepsin. AN Pseudomonas sp. pepstatin-insensitive carboxyl proteinase. AN sedolysin. CA Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15-Leu-|-Tyr-16 CA and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic CA substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO2)-Arg-Leu. CC -!- An enzyme secreted by Pseudomonas sp. No. 101. CC -!- Optimum pH 4. CC -!- It is distinguished from EC 3.4.21.101 by its insensitivity to EPNP CC and from EC 3.4.23.31 by this property and by its unrelated amino- CC acid sequence. CC -!- Inhibited by tyrostatin, a peptide aldehyde. CC -!- Belongs to peptidase family S53. CC -!- Formerly EC 3.4.23.37. DR P42790, PICP_PSESR ; //