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ENZYME entry: EC 3.4.21.103

Accepted Name
Physarolisin.
Alternative Name(s)
Dictyostelium discoideum aspartic proteinase.
Dictyostelium discoideum aspartic proteinase E.
Physaropepsin.
Physarum aspartic proteinase.
Physarum flavicomum aspartic proteinase.
Physarum polycephalum acid proteinase.
Reaction catalysed
Milk clotting activity. Preferential cleavage of 8-Gly-|-Ser-9 in B chain of insulin most rapidly, followed by 11-Leu-|-Val-12, 19-Cys(SO(3)H)-|-Gly and 24-Phe-|-Phe-25. No action on Ac-Phe-Tyr(I)(2)
Comment(s)
  • From the slime mold Physarum polycephalum.
  • Is not inhibited by pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate.
  • Closely similar enzymes are found in Dictyostelium discoideum and P.flavicomum.
  • Belongs to peptidase family S53.
  • Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.27.
Cross-references
BRENDA3.4.21.103
EC2PDB3.4.21.103
ExplorEnz3.4.21.103
PRIAM enzyme-specific profiles3.4.21.103
KEGG Ligand Database for Enzyme Nomenclature3.4.21.103
IUBMB Enzyme Nomenclature3.4.21.103
IntEnz3.4.21.103
MEDLINEFind literature relating to 3.4.21.103
MetaCyc3.4.21.103
UniProtKB/Swiss-Prot
Q8MZS4, PHYSA_PHYPO

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