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ENZYME

ENZYME entry: EC 3.4.21.103

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.103
Accepted Name
physarolisin
Alternative Name(s)
Dictyostelium discoideum aspartic proteinase
Dictyostelium discoideum aspartic proteinase E
physaropepsin
Physarum aspartic proteinase
Physarum flavicomum aspartic proteinase
Physarum polycephalum acid proteinase
Reaction catalysed
Milk clotting activity. Preferential cleavage of 8-Gly-|-Ser-9 in B chain of insulin most rapidly, followed by 11-Leu-|-Val-12, 19-Cys(SO(3)H)-|-Gly and 24-Phe-|-Phe-25. No action on Ac-Phe-Tyr(I)2
Comment(s)
  • From the slime mold Physarum polycephalum.
  • Is not inhibited by pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate.
  • Closely similar enzymes are found in Dictyostelium discoideum and P.flavicomum.
  • Belongs to peptidase family S53.
  • Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.27.
Cross-references
Rhea expert-curated reactions3.4.21.103
ExplorEnz3.4.21.103
IUBMB Enzyme Nomenclature3.4.21.103
UniProtKB/Swiss-Prot
Q8MZS4, PHYSA_BADPO
BRENDA3.4.21.103
MetaCyc3.4.21.103
KEGG Ligand Database for Enzyme Nomenclature3.4.21.103
EC2PDB3.4.21.103
MEDLINEFind literature relating to 3.4.21.103

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