ID 3.4.21.104 DE mannan-binding lectin-associated serine protease-2. AN mannan-binding lectin-associated serine peptidase 2. AN mannose-binding lectin-associated serine protease-2. AN MASP2. AN MASP-2. AN MBP-associated serine protease-2. CA Selective cleavage after Arg-223 in complement component C2 (-Ser- CA Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component CA C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile). CC -!- Mannan-binding lectin (MBL) recognizes patterns of neutral CC carbohydrates, such as mannose and N-acetylglucosamine, on a wide CC range of microbial surfaces and is able to initiate activation of the CC lectin pathway of complement. CC -!- Displays C1s-like esterolytic activity (cf. EC 3.4.21.42). CC -!- It also cleaves C4 and C2 with efficiencies that are relatively CC higher than those of EC 3.4.21.42. CC -!- Belongs to peptidase family S1A. DR O00187, MASP2_HUMAN; Q91WP0, MASP2_MOUSE; Q9JJS8, MASP2_RAT ; //