ID   3.4.21.105
DE   Rhomboid protease.
CA   Cleaves type-1 transmembrane domains using a catalytic dyad composed of
CA   serine and histidine that are contributed by different transmembrane
CA   domains.
CC   -!- These endopeptidases are multi-spanning membrane proteins.
CC   -!- Their catalytic site is embedded within the membrane and they cleave
CC       type-1 transmembrane domains.
CC   -!- Important for embryo development in Drosophila melanogaster.
CC   -!- Rhomboid is a key regulator of EGF receptor signaling and is
CC       responsible for cleaving Spitz, the main ligand of the Drosophila EGF
CC       receptor pathway.
CC   -!- Parasite-encoded rhomboid enzymes are also important for invasion of
CC       host cells by Toxoplasma and the malaria parasite.
CC   -!- Belongs to peptidase family S54.
DR   P46116, AARA_PROST ;  A8AQX4, GLPG_CITK8 ;  A7ZSV4, GLPG_ECO24 ;
DR   B7UKC8, GLPG_ECO27 ;  B7MDQ0, GLPG_ECO45 ;  B7L4V0, GLPG_ECO55 ;
DR   Q8X6Z6, GLPG_ECO57 ;  B5YTX6, GLPG_ECO5E ;  B7NMI8, GLPG_ECO7I ;
DR   B7N156, GLPG_ECO81 ;  B7M2I4, GLPG_ECO8A ;  C4ZVX5, GLPG_ECOBW ;
DR   B1X769, GLPG_ECODH ;  A8A5N2, GLPG_ECOHS ;  A1AGU7, GLPG_ECOK1 ;
DR   Q0TC44, GLPG_ECOL5 ;  Q8FCS5, GLPG_ECOL6 ;  B1IP42, GLPG_ECOLC ;
DR   P09391, GLPG_ECOLI ;  B7NE28, GLPG_ECOLU ;  B6I2Y7, GLPG_ECOSE ;
DR   B1LI84, GLPG_ECOSM ;  Q1R5L1, GLPG_ECOUT ;  A4WFK8, GLPG_ENT38 ;
DR   Q6CZL3, GLPG_ERWCT ;  B7LSC6, GLPG_ESCF3 ;  P44783, GLPG_HAEIN ;
DR   B5XTR5, GLPG_KLEP3 ;  A6TF43, GLPG_KLEP7 ;  Q7N9W4, GLPG_PHOLL ;
DR   B5F8P0, GLPG_SALA4 ;  A9MMA7, GLPG_SALAR ;  Q57IV1, GLPG_SALCH ;
DR   B5FKE3, GLPG_SALDC ;  B5R383, GLPG_SALEP ;  B5R7J1, GLPG_SALG2 ;
DR   B4TKV0, GLPG_SALHS ;  B4SVM1, GLPG_SALNS ;  Q5PLZ8, GLPG_SALPA ;
DR   B5BHH5, GLPG_SALPK ;  B4TY77, GLPG_SALSV ;  Q8Z229, GLPG_SALTI ;
DR   Q8ZLH5, GLPG_SALTY ;  A8GKU2, GLPG_SERP5 ;  B2U3N2, GLPG_SHIB3 ;
DR   Q31VK9, GLPG_SHIBS ;  Q32AN6, GLPG_SHIDS ;  Q0SZP2, GLPG_SHIF8 ;
DR   Q83PV6, GLPG_SHIFL ;  Q3YWA4, GLPG_SHISS ;  Q2NQH3, GLPG_SODGM ;
DR   A1JSF0, GLPG_YERE8 ;  A7FNW6, GLPG_YERP3 ;  Q1C2L2, GLPG_YERPA ;
DR   B2K5W4, GLPG_YERPB ;  Q7CFX8, GLPG_YERPE ;  Q1CCK6, GLPG_YERPN ;
DR   A4TGR2, GLPG_YERPP ;  Q664J1, GLPG_YERPS ;  B1JHY8, GLPG_YERPY ;
DR   P54493, GLUP_BACSU ;  Q2KHV4, PARL_BOVIN ;  Q58EK4, PARL_DANRE ;
DR   Q9H300, PARL_HUMAN ;  Q5XJY4, PARL_MOUSE ;  Q5R5H4, PARL_PONAB ;
DR   Q3B8P0, PARL_RAT   ;  P53259, PCP1_YEAST ;  O75783, RHBL1_HUMAN;
DR   Q8VC82, RHBL1_MOUSE;  O88779, RHBL1_RAT  ;  Q695U0, RHBL1_TOXGO;
DR   Q9NX52, RHBL2_HUMAN;  A2AGA4, RHBL2_MOUSE;  Q695T9, RHBL2_TOXGO;
DR   P58872, RHBL3_HUMAN;  P58873, RHBL3_MOUSE;  Q6IUY1, RHBL3_TOXGO;
DR   Q695T8, RHBL4_TOXGO;  Q6GV23, RHBL5_TOXGO;  Q2PP52, RHBL6_TOXGO;
DR   P20350, RHOM_DROME ;  Q19821, ROM1_CAEEL ;  P34356, ROM2_CAEEL ;
//