ID   3.4.21.106
DE   hepsin.
CA   Cleavage after basic amino-acid residues, with Arg strongly preferred to
CA   Lys.
CC   -!- This type-II membrane-associated serine peptidase has been implicated
CC       in cell growth and development.
CC   -!- The enzyme has been shown to activate blood coagulation factor VII by
CC       cleavage of the 152-Arg-|-Ile-153 peptide bound in BHK cells, thus
CC       indicating a possible role in the initiation of blood coagulation.
CC   -!- There is no cleavage after aromatic or aliphatic residues.
CC   -!- The occupancy of the S2 site is an absolute requirement for catalysis
CC       and a basic residue at that site is preferred to an aliphatic
CC       residue.
CC   -!- The nature of the residue at S3 also affects hydrolysis, with Gln
CC       being much more favorable than Ala.
CC   -!- Belongs to peptidase family S1A.
DR   P05981, HEPS_HUMAN ;  O35453, HEPS_MOUSE ;  Q5R5E8, HEPS_PONAB ;
DR   Q05511, HEPS_RAT   ;
//