ID 3.4.21.108 DE HtrA2 peptidase. AN high temperature requirement protein A2. AN HtrA2 protease. AN Omi stress-regulated endoprotease. AN serine proteinase OMI. CA Cleavage of non-polar aliphatic amino-acids at the P1 position, with a CA preference for Val, Ile and Met. At the P2 and P3 positions, Arg is CA selected most strongly with a secondary preference for other hydrophilic CA residues. CC -!- Up-regulated in mammalian cells in response to stress induced by both CC heat shock and tunicamycin treatment. CC -!- Can induce apoptosis in a caspase-independent manner through its CC peptidase activity and in a caspase-dependent manner by disrupting CC the interaction between caspase and the inhibitor of apoptosis (IAP). CC -!- Belongs to peptidase family S1B. DR A0JNK3, HTRA2_BOVIN; B3LVG7, HTRA2_DROAN; B3P3J9, HTRA2_DROER; DR B4JTT7, HTRA2_DROGR; Q9VFJ3, HTRA2_DROME; B4K835, HTRA2_DROMO; DR B4G316, HTRA2_DROPE; Q297U2, HTRA2_DROPS; B4HEM8, HTRA2_DROSE; DR B4QZU6, HTRA2_DROSI; B4LY58, HTRA2_DROVI; B4N937, HTRA2_DROWI; DR B4PST0, HTRA2_DROYA; O43464, HTRA2_HUMAN; Q9JIY5, HTRA2_MOUSE; //