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ENZYME entry: EC 184.108.40.206
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|Membrane-type serine protease 1.|
|Serine endopeptidase SNC19.|
|Serine protease 14.|
|Serine protease TADG-15.|
|Tumor-associated differentially-expressed gene 15 protein.|
|Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position|
- This trypsin-like integral-membrane serine peptidase has been
implicated in breast cancer invasion and metastasis.
- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by
cleavage of the two-chain form at an Arg residue to give active
alpha- and beta-HGF, but it does not activate plasminogen, which
shares high homology with HGF.
- Can also activate urokinase plasminogen activator (uPA), which
initiates the matrix-degrading peptidase cascade.
- Belongs to peptidase family S1A.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
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entries corresponding to 3.4.21.-
entries corresponding to 3.4.-.-
entries corresponding to 3.-.-.-