Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC

Accepted Name
Alternative Name(s)
Membrane-type serine protease 1.
Serine endopeptidase SNC19.
Serine protease 14.
Serine protease TADG-15.
Tumor-associated differentially-expressed gene 15 protein.
Reaction catalysed
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
  • This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.
  • Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF.
  • Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade.
  • Belongs to peptidase family S1A.
PRIAM enzyme-specific profiles3.4.21.109
KEGG Ligand Database for Enzyme Nomenclature3.4.21.109
IUBMB Enzyme Nomenclature3.4.21.109
MEDLINEFind literature relating to
Q0IIH7, ST14_BOVIN;  Q9Y5Y6, ST14_HUMAN;  P56677, ST14_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-