ENZYME entry: EC 3.4.21.109

Accepted Name
Matriptase.
Alternative Name(s)
Epithin.
Membrane-type serine protease 1.
MT-SP1.
Prostamin.
Serine endopeptidase SNC19.
Serine protease 14.
Serine protease TADG-15.
Tumor-associated differentially-expressed gene 15 protein.
Reaction catalysed
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment(s)
  • This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.
  • Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF.
  • Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade.
  • Belongs to peptidase family S1A.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.109
EC2PDB3.4.21.109
ExplorEnz3.4.21.109
PRIAM enzyme-specific profiles3.4.21.109
KEGG Ligand Database for Enzyme Nomenclature3.4.21.109
IUBMB Enzyme Nomenclature3.4.21.109
IntEnz3.4.21.109
MEDLINEFind literature relating to 3.4.21.109
MetaCyc3.4.21.109
UniProtKB/Swiss-Prot
Q0IIH7, ST14_BOVIN;  Q9Y5Y6, ST14_HUMAN;  P56677, ST14_MOUSE;  

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