ID   3.4.21.110
DE   C5a peptidase.
AN   SCP.
AN   streptococcal C5a peptidase.
CA   The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor
CA   secondary cleavage site at 58-Ala-|-Ser-59.
CC   -!- Surface-associated subtilisin-like serine peptidase with very
CC       specific substrate specificity.
CC   -!- Virulent strains of streptococci, including Streptococcus pyogenes,
CC       can evade human detection and phagocytosis by destroying the
CC       complement chemotaxin C5a.
CC   -!- Cleavage of human C5a by this enzyme reduces the ability of C5a to
CC       bind receptors on the surface of polymorphonuclear neutrophil
CC       leukocytes (PMNLs) and thereby abolishes its chemotactic properties.
CC   -!- Belongs to peptidase family S8A.
DR   P58099, C5AP_STRP1 ;  P0DD34, C5AP_STRP3 ;  Q5X9R0, C5AP_STRP6 ;
DR   Q8NZ80, C5AP_STRP8 ;  P0DD35, C5AP_STRPQ ;  P15926, C5AP_STRPY ;
//