ID 3.4.21.112 DE site-1 protease. AN mammalian subtilisin/kexin isozyme 1. AN membrane-bound transcription factor site-1 protease. AN proprotein convertase SKI-1. AN proprotein convertase SKI-1/S1PPS1. AN S1P endopeptidase. AN S1P protease. AN site-1 peptidase. AN SKI-1. AN SREBP-1 proteinase. AN SREBP-2 proteinase. AN SREBP proteinase. AN SREBP S1 protease. AN sterol-regulated luminal protease. AN sterol regulatory element-binding protein proteinase. AN sterol regulatory element-binding protein site 1 protease. AN subtilase SKI-1. AN subtilase SKI-1/S1P. AN subtilisin/kexin isozyme 1. CA Processes precursors containing basic and hydrophobic/aliphatic residues CA at P4 and P2, respectively, with a relatively relaxed acceptance of amino CA acids at P1 and P3. CC -!- Cleaves sterol regulatory element-binding proteins (SREBPs) and CC thereby initiates a process by which the active fragments of the CC SREBPs translocate to the nucleus and activate genes controlling the CC synthesis and uptake of cholesterol and unsaturated fatty acids into CC the bloodstream. CC -!- The enzyme also processes pro-brain-derived neurotrophic factor and CC undergoes autocatalytic activation in the endoplasmic reticulum CC through sequential cleavages. CC -!- The enzyme can also process the unfolded protein response stress CC factor ATF6 at an Arg-His-Lys-Lys-|- site, and the envelope CC glycoprotein of the highly infectious Lassa virus and Crimean Congo CC hemorrhagic fever virus at Arg-Arg-Lys-Lys-|-. CC -!- Belongs to peptidase family S8A. DR Q9Z2A8, MBTP1_CRIGR; Q14703, MBTP1_HUMAN; Q9WTZ2, MBTP1_MOUSE; DR Q9WTZ3, MBTP1_RAT ; //