ID   3.4.21.113
DE   pestivirus NS3 polyprotein peptidase.
AN   BDV NS3 endopeptidase.
AN   border disease virus NS3 endopeptidase.
AN   bovine viral diarrhea virus NS3 endopeptidase.
AN   BVDV NS3 endopeptidase.
AN   classical swine fever virus NS3 endopeptidase.
AN   CSFV NS3 endopeptidase.
CA   Leu is conserved at position P1 for all four cleavage sites. Alanine is
CA   found at position P1' of the NS4A-NS4B cleavage site, whereas serine is
CA   found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage
CA   sites.
CC   -!- The polyprotein of noncytopathogenic pestiviruses is cleaved co- and
CC       post-translationally into at least 11 proteins (N(pro), C, E(rns),
CC       E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B).
CC   -!- The genomes of cytopathogenic pestivirus strains express at least one
CC       additional protein, called NS3 (p80).
CC   -!- This enzyme, which resides in the N-terminal region of NS3 (non-
CC       structural protein 3), is essential for generation of its own
CC       C-terminus and for processing of the downstream cleavage sites,
CC       leading to the release of the pestivirus non-structural proteins
CC       NS4A, NS4B, NS5A and NS5B.
CC   -!- Belongs to peptidase family S31.
DR   Q96662, POLG_BVDVC ;  P19711, POLG_BVDVN ;  Q01499, POLG_BVDVS ;
DR   P19712, POLG_CSFVA ;  P21530, POLG_CSFVB ;
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