ID   3.4.21.114
DE   equine arterivirus serine peptidase.
AN   3C-like serine protease.
AN   3C-like Ser protease.
AN   3CLSP.
AN   arterivirus NSP4.
AN   chymotrypsin-like serine proteinase nsp4.
AN   equine arteritis virus serine peptidase.
AN   non-structural protein 4 serine protease.
CA   Cleavage of (Glu/Gln)-|-(Gly/Ser/Ala) in arterivirus replicase
CA   translation products ORF1a and ORF1ab.
CC   -!- In the equine arterivirus (EAV), the replicase gene is translated
CC       into open reading frame 1a (ORF1a) and ORF1ab polyproteins.
CC   -!- This enzyme is the main viral proteinase and processes five cleavage
CC       sites in the ORF1a protein and three in the ORF1b-encoded part of the
CC       ORF1ab protein to yield non-structural proteins (nsp5-nsp12).
CC   -!- It combines the catalytic system of a chymotrypsin-like serine
CC       peptidase (His-Asp-Ser catalytic triad) with the substrate
CC       specificity of a 3C-like serine peptidase (Glu or Gln) at the P1
CC       position and a small amino-acid residue (Gly, Ser or Ala) at the P1'
CC       position.
CC   -!- Cleavage of ORF1ab by this enzyme is essential for viral replication.
CC   -!- Belongs to peptidase family S32.
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