ID 3.4.21.116 DE SpoIVB peptidase. AN sporulation factor IV B protease. AN stage IV sporulation protein B. CA Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the CA N-terminus of SpoIVB. CC -!- This enzyme plays a central role in a regulatory checkpoint (the CC sigma(K) checkpoint), which coordinates gene expression during the CC later stages of spore formation in Bacillus subtilis. CC -!- The enzyme activates proteolytic processing of a sporulation-specific CC sigma factor, pro-sigma(K), to its mature and active form, sigma(K), CC by self-cleavage. CC -!- The enzyme is also subject to secondary proteolysis, which presumably CC inactivates SpoIVB. CC -!- The enzyme is also essential for the formation of heat-resistant CC spores. CC -!- Belongs to peptidase family S55. DR P17896, SP4B_BACSU ; //