ENZYME entry: EC 3.4.21.117

Accepted Name
Stratum corneum chymotryptic enzyme.
Alternative Name(s)
Kallikrein 7.
SCCE.
Serine protease 6.
Reaction catalysed
Cleavage of proteins with aromatic side chains in the P1 position
Comment(s)
  • This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen.
  • It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27.
  • It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures.
  • Belongs to peptidase family S1A.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.117
EC2PDB3.4.21.117
ExplorEnz3.4.21.117
PRIAM enzyme-specific profiles3.4.21.117
KEGG Ligand Database for Enzyme Nomenclature3.4.21.117
IUBMB Enzyme Nomenclature3.4.21.117
IntEnz3.4.21.117
MEDLINEFind literature relating to 3.4.21.117
MetaCyc3.4.21.117
UniProtKB/Swiss-Prot
P49862, KLK7_HUMAN;  Q91VE3, KLK7_MOUSE;  

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