ID   3.4.21.118
DE   kallikrein 8.
AN   neuropsin.
AN   ovasin.
AN   serine protease 19.
AN   TADG-14.
AN   tumor-associated differentially expressed gene 14.
CA   Cleavage of amide substrates following the basic amino acids Arg or Lys
CA   at the P1 position, with a preference for Arg over Lys.
CC   -!- Activated by removal of an N-terminal prepropeptide.
CC   -!- The highest amidolytic activity is observed using Boc-Val-Pro-
CC       Arg-|-7-amido-4-methylcoumarin, which is a substrate of alpha-
CC       thrombin.
CC   -!- Substrates lacking basic amino acids in the P1 position are not
CC       cleaved.
CC   -!- Degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen,
CC       and high-molecular-mass kininogen and is associated with diseases
CC       such as ovarian cancer and Alzheimer's disease.
CC   -!- Belongs to peptidase family S1A.
DR   O60259, KLK8_HUMAN ;  Q61955, KLK8_MOUSE ;  O88780, KLK8_RAT   ;
//