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ENZYME entry: EC 126.96.36.199
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|Epidermal growth factor-binding protein type B.|
|Prorenin converting enzyme 1.|
|Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin|
- Specific for prorenin from the mouse submandibular gland, as prorenin
from the mouse kidney (Ren1) and human prorenin are not substrates.
- Site-directed mutagenesis studies have shown that the enzyme will
also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg
but the rate of reaction is much slower when Lys-Lys is used.
- Also able to process pro-interleukin-1-beta (pro-IL-1-beta) in mouse
submandibular gland to form IL-1-beta.
- Belongs to peptidase family S1A.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
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entries corresponding to 3.4.21.-
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entries corresponding to 3.-.-.-