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ENZYME entry: EC

Accepted Name
Alternative Name(s)
Oviductal protease.
Reaction catalysed
Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41
  • The egg envelope of Xenopus laevis is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form.
  • This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin.
  • It is thought that the enzymatically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions.
  • Also found in Bufo japonicus.
  • Belongs to peptidase family S1.
PRIAM enzyme-specific profiles3.4.21.120
KEGG Ligand Database for Enzyme Nomenclature3.4.21.120
IUBMB Enzyme Nomenclature3.4.21.120
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