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ENZYME entry: EC 3.4.21.120

Accepted Name
Oviductin.
Alternative Name(s)
Oviductal protease.
Ovochymase-2.
Reaction catalysed
Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41
Comment(s)
  • The egg envelope of Xenopus laevis is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form.
  • This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin.
  • It is thought that the enzymatically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions.
  • Also found in Bufo japonicus.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.120
EC2PDB3.4.21.120
ExplorEnz3.4.21.120
PRIAM enzyme-specific profiles3.4.21.120
KEGG Ligand Database for Enzyme Nomenclature3.4.21.120
IUBMB Enzyme Nomenclature3.4.21.120
IntEnz3.4.21.120
MEDLINEFind literature relating to 3.4.21.120
MetaCyc3.4.21.120
UniProtKB/Swiss-Prot
Q90WD8, OVCH2_BUFJA;  Q66TN7, OVCH2_RHIAE;  P79953, OVCH2_XENLA;  

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