ENZYME

ENZYME entry: EC 3.4.21.120

Accepted Name

Oviductin.

Alternative Name(s)

Oviductal protease.

Ovochymase-2.

Reaction catalysed

Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41

Comment(s)

The egg envelope of Xenopus laevis is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form.
This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin.
It is thought that the enzymatically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions.
Also found in Bufo japonicus.
Belongs to peptidase family S1.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature