ENZYME entry: EC 3.4.21.34

Accepted Name
Plasma kallikrein.
Alternative Name(s)
Kininogenin.
Serum kallikrein.
Reaction catalysed
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin
Comment(s)
  • Formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
  • Activates coagulation factors XII, VII and plasminogen.
  • Selective for Arg > Lys in P1, in small molecule substrates.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.21 and EC 3.4.21.8.
Cross-references
PROSITEPDOC00124 ; PDOC00376
BRENDA3.4.21.34
EC2PDB3.4.21.34
ExplorEnz3.4.21.34
PRIAM enzyme-specific profiles3.4.21.34
KEGG Ligand Database for Enzyme Nomenclature3.4.21.34
IUBMB Enzyme Nomenclature3.4.21.34
IntEnz3.4.21.34
MEDLINEFind literature relating to 3.4.21.34
MetaCyc3.4.21.34
UniProtKB/Swiss-Prot
Q2KJ63, KLKB1_BOVIN;  P03952, KLKB1_HUMAN;  P26262, KLKB1_MOUSE;  
P14272, KLKB1_RAT;  

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