ID 3.4.21.35 DE tissue kallikrein. AN glandular kallikrein. AN kininogenin. CA Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. CA Highly selective action to release kallidin (lysyl-bradykinin) from CA kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. CC -!- Formed from tissue prokallikrein by activation with trypsin. CC -!- A large number of tissue kallikrein-related sequences have been CC reported for rats and mice, though fewer seem to exist in other CC mammals. CC -!- The few that have been isolated and tested on substrates include CC mouse EC 3.4.21.54, submandibular proteinase a, epidermal growth- CC factor-binding protein, nerve growth factor gamma-subunit, rat tonin, CC submaxillary proteinases A and B, T-kininogenase, kallikreins K7 and CC K8. CC -!- The rat enzyme is unusual in liberating bradykinin directly from CC autologous kininogens by cleavage at two Arg-|-Xaa bonds. CC -!- Belongs to peptidase family S1. CC -!- Formerly EC 3.4.21.8. DR P09582, ESTA_CANLF ; P15946, K1B11_MOUSE; Q61759, K1B21_MOUSE; DR P15948, K1B22_MOUSE; Q61754, K1B24_MOUSE; P36369, K1B26_MOUSE; DR P00755, K1KB1_MOUSE; P00756, K1KB3_MOUSE; P15945, K1KB5_MOUSE; DR P07628, K1KB8_MOUSE; P15949, K1KB9_MOUSE; P36375, KLK10_RAT ; DR P36376, KLK12_RAT ; P12322, KLK1_CAVPO ; P06870, KLK1_HUMAN ; DR Q07276, KLK1_MACFA ; P15947, KLK1_MOUSE ; Q28773, KLK1_PAPHA ; DR P00758, KLK1_RAT ; P12323, KLK2_CAVPO ; Q6H321, KLK2_HORSE ; DR P20151, KLK2_HUMAN ; P00759, KLK2_RAT ; P15950, KLK3_RAT ; DR P36374, KLK6_RAT ; P36373, KLK7_RAT ; P07647, KLK9_RAT ; DR P32824, KLKR_MASNA ; P00752, KLK_PIG ; //