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ENZYME entry: EC 220.127.116.11
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|Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to form thrombin and two inactive fragments|
- From the venom of the Taipan snake (Oxyuranus scutellatus).
- Converts prothrombin to thrombin.
- Specificity is similar to that of Factor Xa (EC 18.104.22.168).
- However, unlike Factor Xa this enzyme can cleave its target in the
absence of coagulation Factor Va.
- Activity is potentiated by phospholipid and Ca(2+) which binds via
gamma-carboxyglutamic acid residues.
- Similar enzymes are known from the venom of other Australian elapid
snakes, including Pseudonaja textilis textilis, Oxyuranus
microlepidotus and Demansia nuchalis affinis.
- Formerly EC 22.214.171.124.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
entries corresponding to 3.4.21.-
entries corresponding to 3.4.-.-
entries corresponding to 3.-.-.-