ENZYME entry: EC 3.4.21.60
| Accepted Name |
|---|
| Scutelarin.
|
| Alternative Name(s) |
|---|
| Taipan activator. |
| Reaction catalysed |
|---|
| Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to form thrombin and two inactive fragments |
| Comment(s) |
|---|
- From the venom of the Taipan snake (Oxyuranus scutellatus).
- Converts prothrombin to thrombin.
- Specificity is similar to that of Factor Xa (EC 3.4.21.6).
- However, unlike Factor Xa this enzyme can cleave its target in the
absence of coagulation Factor Va.
- Activity is potentiated by phospholipid and Ca(2+) which binds via
gamma-carboxyglutamic acid residues.
- Similar enzymes are known from the venom of other Australian elapid
snakes, including Pseudonaja textilis textilis, Oxyuranus
microlepidotus and Demansia nuchalis affinis.
- Formerly EC 3.4.99.28.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.60 |
| EC2PDB | 3.4.21.60 |
| ExplorEnz | 3.4.21.60 |
| PRIAM enzyme-specific profiles | 3.4.21.60 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.60 |
| IUBMB Enzyme Nomenclature | 3.4.21.60 |
| IntEnz | 3.4.21.60 |
| MEDLINE | Find literature relating to 3.4.21.60 |
| MetaCyc | 3.4.21.60 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-