ENZYME entry: EC 3.4.21.60

Accepted Name
Scutelarin.
Alternative Name(s)
Taipan activator.
Reaction catalysed
Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to form thrombin and two inactive fragments
Comment(s)
  • From the venom of the Taipan snake (Oxyuranus scutellatus).
  • Converts prothrombin to thrombin.
  • Specificity is similar to that of Factor Xa (EC 3.4.21.6).
  • However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va.
  • Activity is potentiated by phospholipid and Ca(2+) which binds via gamma-carboxyglutamic acid residues.
  • Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis.
  • Formerly EC 3.4.99.28.
Cross-references
BRENDA3.4.21.60
EC2PDB3.4.21.60
ExplorEnz3.4.21.60
PRIAM enzyme-specific profiles3.4.21.60
KEGG Ligand Database for Enzyme Nomenclature3.4.21.60
IUBMB Enzyme Nomenclature3.4.21.60
IntEnz3.4.21.60
MEDLINEFind literature relating to 3.4.21.60
MetaCyc3.4.21.60

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