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ENZYME entry: EC

Accepted Name
Reaction catalysed
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides
  • Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin.
  • It contains no cysteine residues (although these are found in homologous enzymes).
  • Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo).
  • Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species.
  • Belongs to peptidase family S8.
  • Formerly EC and EC
PRIAM enzyme-specific profiles3.4.21.62
KEGG Ligand Database for Enzyme Nomenclature3.4.21.62
IUBMB Enzyme Nomenclature3.4.21.62
MEDLINEFind literature relating to
P09230, AEP_YARLI;  P29599, SUBB_BACLE;  P00781, SUBD_BACLI;  
P35835, SUBN_BACNA;  P29600, SUBS_BACLE;  P00782, SUBT_BACAM;  
P00780, SUBT_BACLI;  P07518, SUBT_BACPU;  P28842, SUBT_BACS9;  
P00783, SUBT_BACSA;  P04189, SUBT_BACSU;  P29142, SUBT_GEOSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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