ENZYME entry: EC 3.4.21.72

Accepted Name
IgA-specific serine endopeptidase.
Alternative Name(s)
IgA protease.
Immunoglobulin A1 protease.
Reaction catalysed
Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known
Comment(s)
  • Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae.
  • Some other bacterial endopeptidases with similar specificity are of metallotype (see EC 3.4.24.13).
  • Belongs to peptidase family S6.
Cross-references
BRENDA3.4.21.72
EC2PDB3.4.21.72
ExplorEnz3.4.21.72
PRIAM enzyme-specific profiles3.4.21.72
KEGG Ligand Database for Enzyme Nomenclature3.4.21.72
IUBMB Enzyme Nomenclature3.4.21.72
IntEnz3.4.21.72
MEDLINEFind literature relating to 3.4.21.72
MetaCyc3.4.21.72
UniProtKB/Swiss-Prot
P44969, IGA0_HAEIN;  P42782, IGA1_HAEIF;  P45384, IGA2_HAEIF;  
P45385, IGA3_HAEIF;  P45386, IGA4_HAEIF;  P09790, IGA_NEIGO;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-