ENZYME entry: EC 3.4.21.88

Accepted Name
Repressor LexA.
Reaction catalysed
Hydrolysis of Ala-|-Gly bond in repressor LexA
Comment(s)
  • In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  • The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37).
  • Belongs to peptidase family S24.
Cross-references
BRENDA3.4.21.88
EC2PDB3.4.21.88
ExplorEnz3.4.21.88
PRIAM enzyme-specific profiles3.4.21.88
KEGG Ligand Database for Enzyme Nomenclature3.4.21.88
IUBMB Enzyme Nomenclature3.4.21.88
IntEnz3.4.21.88
MEDLINEFind literature relating to 3.4.21.88
MetaCyc3.4.21.88
UniProtKB/Swiss-Prot
P61608, LEXA1_GEOSL;  Q5YP21, LEXA1_NOCFA;  P0A153, LEXA1_PSEPK;  
Q87ZB9, LEXA1_PSESM;  Q8PN77, LEXA1_XANAC;  Q8PBM1, LEXA1_XANCP;  
Q5GX75, LEXA1_XANOR;  P61609, LEXA2_GEOSL;  Q5YT43, LEXA2_NOCFA;  
P59479, LEXA2_PSEPK;  Q881U0, LEXA2_PSESM;  P60511, LEXA2_XANAC;  
Q8P9X2, LEXA2_XANCP;  Q5GYM5, LEXA2_XANOR;  A1TQ93, LEXA_ACIAC;  
A0LUZ1, LEXA_ACIC1;  A5G2J1, LEXA_ACICJ;  B9MI78, LEXA_ACIET;  
B7JBX0, LEXA_ACIF2;  B5EJ91, LEXA_ACIF5;  A1W897, LEXA_ACISJ;  
A3N1B4, LEXA_ACTP2;  B3GXZ4, LEXA_ACTP7;  B0BQ48, LEXA_ACTPJ;  
A6VMQ0, LEXA_ACTSZ;  Q44069, LEXA_AERHH;  A4STB3, LEXA_AERS4;  
B9JEY4, LEXA_AGRRK;  Q8UFK2, LEXA_AGRT5;  B9JX59, LEXA_AGRVS;  
Q21U48, LEXA_ALBFT;  Q0VQU1, LEXA_ALCBS;  B6ENU0, LEXA_ALISL;  
Q0A9N9, LEXA_ALKEH;  A6TR70, LEXA_ALKMQ;  A8MFC9, LEXA_ALKOO;  
B4S1W7, LEXA_ALTMD;  B8JA57, LEXA_ANAD2;  Q2IIJ0, LEXA_ANADE;  
A7HC61, LEXA_ANADF;  B4UCX8, LEXA_ANASK;  Q5P4A1, LEXA_AROAE;  
A1R556, LEXA_ARTAT;  B8HG97, LEXA_ARTCA;  A0JUZ2, LEXA_ARTS2;  
A8I825, LEXA_AZOC5;  A1K776, LEXA_AZOSB;  C1DQZ4, LEXA_AZOVD;  
A7Z552, LEXA_BACA2;  A0RH75, LEXA_BACAH;  Q81Y06, LEXA_BACAN;  
B7JIC6, LEXA_BACC0;  P61606, LEXA_BACC1;  A7GR32, LEXA_BACCN;  
B9IUL2, LEXA_BACCQ;  Q81A92, LEXA_BACCR;  Q637D7, LEXA_BACCZ;  
Q9KAD3, LEXA_BACHD;  Q6HFB0, LEXA_BACHK;  Q65J42, LEXA_BACLD;  
A8FDP7, LEXA_BACP2;  Q5WG03, LEXA_BACSK;  P31080, LEXA_BACSU;  
A9VPX5, LEXA_BACWK;  Q6G5D9, LEXA_BARHE;  Q6FZU5, LEXA_BARQU;  
B2IKM0, LEXA_BEII9;  A1A2G3, LEXA_BIFAA;  B3DQB4, LEXA_BIFLD;  
Q8G4R6, LEXA_BIFLO;  B7GQ64, LEXA_BIFLS;  Q2L247, LEXA_BORA1;  
Q7WCK0, LEXA_BORBR;  Q7W0T5, LEXA_BORPA;  A9IR25, LEXA_BORPD;  
Q7VRY0, LEXA_BORPE;  Q89KS7, LEXA_BRADU;  A5EK34, LEXA_BRASB;  
A4YVE6, LEXA_BRASO;  C0ZES6, LEXA_BREBN;  B2S5Z4, LEXA_BRUA1;  
Q2YRR1, LEXA_BRUA2;  Q57CZ5, LEXA_BRUAB;  A9M5F7, LEXA_BRUC2;  
C0RJB4, LEXA_BRUMB;  Q8YHG1, LEXA_BRUME;  A5VQR8, LEXA_BRUO2;  
B0CGU2, LEXA_BRUSI;  Q8G0F1, LEXA_BRUSU;  B1YPM6, LEXA_BURA4;  
Q1BWH8, LEXA_BURCA;  B1K0Z6, LEXA_BURCC;  A0K775, LEXA_BURCH;  
B4E8S4, LEXA_BURCJ;  Q0BFL9, LEXA_BURCM;  A9AIX7, LEXA_BURM1;  
A3MJD2, LEXA_BURM7;  A2S339, LEXA_BURM9;  Q62K79, LEXA_BURMA;  
A1V472, LEXA_BURMS;  A3NUV3, LEXA_BURP0;  Q3JSP6, LEXA_BURP1;  
A3N959, LEXA_BURP6;  B2JK89, LEXA_BURP8;  B2T3L9, LEXA_BURPP;  
Q63TX7, LEXA_BURPS;  Q39GT3, LEXA_BURS3;  Q2SVP7, LEXA_BURTA;  
A4JE56, LEXA_BURVG;  Q13ZI7, LEXA_BURXL;  A4XL42, LEXA_CALS8;  
Q3ACC4, LEXA_CARHZ;  Q9A724, LEXA_CAUCR;  B0SYZ8, LEXA_CAUSK;  
B3PEX1, LEXA_CELJU;  Q11HT8, LEXA_CHESB;  Q1QVT7, LEXA_CHRSD;  
A8AN85, LEXA_CITK8;  A5CSL0, LEXA_CLAM3;  B0RHB3, LEXA_CLAMS;  
Q97I23, LEXA_CLOAB;  A7FUK4, LEXA_CLOB1;  C3KX30, LEXA_CLOB6;  
A5I2R7, LEXA_CLOBH;  C1FNT4, LEXA_CLOBJ;  B1IM63, LEXA_CLOBK;  
A7GE39, LEXA_CLOBL;  B1KS97, LEXA_CLOBM;  B8I2Q1, LEXA_CLOCE;  
B9E1Z5, LEXA_CLOK1;  A5N8J0, LEXA_CLOK5;  A0Q0N2, LEXA_CLONN;  
Q0TRD0, LEXA_CLOP1;  Q8XL81, LEXA_CLOPE;  Q0STQ8, LEXA_CLOPS;  
Q895H6, LEXA_CLOTE;  A3DDH9, LEXA_CLOTH;  Q48AA9, LEXA_COLP3;  
P61607, LEXA_CORDI;  Q8FPF5, LEXA_COREF;  A4QET8, LEXA_CORGB;  
Q8NP86, LEXA_CORGL;  Q4JV87, LEXA_CORJK;  A7MPP3, LEXA_CROS8;  
Q9AGM5, LEXA_CUPNE;  Q0K9E3, LEXA_CUPNH;  Q46ZR1, LEXA_CUPPJ;  
B3R2P9, LEXA_CUPTR;  Q47EP6, LEXA_DECAR;  O32506, LEXA_DEIRA;  
A9BWH9, LEXA_DELAS;  B8FIX5, LEXA_DESAA;  Q314F2, LEXA_DESAG;  
B8FWD3, LEXA_DESHD;  Q24X76, LEXA_DESHY;  A4J5P4, LEXA_DESRM;  
A8LMK0, LEXA_DINSH;  A7ZUR5, LEXA_ECO24;  B7UPK4, LEXA_ECO27;  
B7MJ33, LEXA_ECO45;  B7LAZ0, LEXA_ECO55;  P0A7C4, LEXA_ECO57;  
B5Z184, LEXA_ECO5E;  B7NSK5, LEXA_ECO7I;  B7N2Q0, LEXA_ECO81;  
B7M7V6, LEXA_ECO8A;  C5A136, LEXA_ECOBW;  B1XC42, LEXA_ECODH;  
A8A7E3, LEXA_ECOHS;  A1AIM0, LEXA_ECOK1;  Q0TA20, LEXA_ECOL5;  
P0A7C3, LEXA_ECOL6;  B1IUK9, LEXA_ECOLC;  P0A7C2, LEXA_ECOLI;  
B7NFY7, LEXA_ECOLU;  B6I5Q8, LEXA_ECOSE;  B1LPK8, LEXA_ECOSM;  
Q1R3P3, LEXA_ECOUT;  C5B718, LEXA_EDWI9;  A4W5F6, LEXA_ENT38;  
Q834R0, LEXA_ENTFA;  B2VKA1, LEXA_ERWT9;  Q2NA93, LEXA_ERYLH;  
B7LL15, LEXA_ESCF3;  B1YE71, LEXA_EXIS2;  C4L2T2, LEXA_EXISA;  
B0S1C5, LEXA_FINM2;  Q0RDY1, LEXA_FRAAA;  Q2J779, LEXA_FRASC;  
A8L6K4, LEXA_FRASN;  B5EA68, LEXA_GEOBB;  Q5L0C3, LEXA_GEOKA;  
Q39VQ1, LEXA_GEOMG;  C6DZY8, LEXA_GEOSM;  C5D9K3, LEXA_GEOSW;  
A4IMK1, LEXA_GEOTN;  A5GAQ4, LEXA_GEOUR;  A9HJ64, LEXA_GLUDA;  
Q5FNN8, LEXA_GLUOX;  Q0BTY8, LEXA_GRABC;  Q7VNI6, LEXA_HAEDU;  
Q4QME9, LEXA_HAEI8;  A5UDX6, LEXA_HAEIE;  A5UHQ3, LEXA_HAEIG;  
P44858, LEXA_HAEIN;  B8F317, LEXA_HAEPS;  Q2SKC5, LEXA_HAHCH;  
A1WXU3, LEXA_HALHL;  A9B5H8, LEXA_HERA2;  A4G713, LEXA_HERAR;  
Q0I2G7, LEXA_HISS1;  B0USF0, LEXA_HISS2;  Q0C1A3, LEXA_HYPNA;  
Q5QUP5, LEXA_IDILO;  A6SXJ3, LEXA_JANMA;  Q28R71, LEXA_JANSC;  
B5XXY9, LEXA_KLEP3;  A6TGV2, LEXA_KLEP7;  Q1IU64, LEXA_KORVE;  
Q5FJL4, LEXA_LACAC;  Q03B55, LEXA_LACC3;  B3WC17, LEXA_LACCB;  
Q1G9M5, LEXA_LACDA;  Q049T1, LEXA_LACDB;  B2GBL2, LEXA_LACF3;  
Q044D8, LEXA_LACGA;  A8YVS7, LEXA_LACH4;  P61610, LEXA_LACJO;  
Q88VI6, LEXA_LACPL;  A5VJB8, LEXA_LACRD;  B2G6T4, LEXA_LACRJ;  
Q1WUI6, LEXA_LACS1;  Q38W54, LEXA_LACSS;  Q6AE10, LEXA_LEIXX;  
B0SFV4, LEXA_LEPBA;  Q04RH1, LEXA_LEPBJ;  Q053A1, LEXA_LEPBL;  
B0SPA2, LEXA_LEPBP;  B1Y250, LEXA_LEPCP;  P61611, LEXA_LEPIC;  
Q8F663, LEXA_LEPIN;  B1MZ70, LEXA_LEUCK;  Q03WX0, LEXA_LEUMM;  
Q92C51, LEXA_LISIN;  C1L2K9, LEXA_LISMC;  Q720B9, LEXA_LISMF;  
B8DG25, LEXA_LISMH;  Q8Y7H7, LEXA_LISMO;  A0AIA3, LEXA_LISW6;  
B1HRJ5, LEXA_LYSSC;  Q2W3A5, LEXA_MAGSA;  A0L9E2, LEXA_MAGSM;  
Q65UK9, LEXA_MANSM;  A1U269, LEXA_MARAV;  Q0APU7, LEXA_MARMM;  
A6VX60, LEXA_MARMS;  Q605V8, LEXA_METCA;  B8IN87, LEXA_METNO;  
A2SGY5, LEXA_METPP;  B1LUJ7, LEXA_METRJ;  B0UGH4, LEXA_METS4;  
B8EK86, LEXA_METSB;  Q2RJF5, LEXA_MOOTA;  A0QIQ3, LEXA_MYCA1;  
B1MCZ5, LEXA_MYCA9;  Q7TY15, LEXA_MYCBO;  A1KM58, LEXA_MYCBP;  
C1AFH9, LEXA_MYCBT;  A4TCN9, LEXA_MYCGI;  B8ZQU5, LEXA_MYCLB;  
Q49848, LEXA_MYCLE;  B2HLX8, LEXA_MYCMM;  P61612, LEXA_MYCPA;  
A0QVY5, LEXA_MYCS2;  A3PYG6, LEXA_MYCSJ;  A1UF04, LEXA_MYCSK;  
Q1BA08, LEXA_MYCSS;  A5U672, LEXA_MYCTA;  P9WHR6, LEXA_MYCTO;  
P9WHR7, LEXA_MYCTU;  A0PT76, LEXA_MYCUA;  A1T7V4, LEXA_MYCVP;  
Q1D406, LEXA_MYXXD;  Q1QMK3, LEXA_NITHX;  Q3SRJ0, LEXA_NITWN;  
A1SND2, LEXA_NOCSJ;  Q2G6Q5, LEXA_NOVAD;  Q8EQM5, LEXA_OCEIH;  
A6X0K7, LEXA_OCHA4;  Q04F93, LEXA_OENOB;  B6JG34, LEXA_OLICO;  
A1B3Z0, LEXA_PARDP;  A7HY01, LEXA_PARL1;  P57917, LEXA_PASMU;  
Q6D9I5, LEXA_PECAS;  Q04596, LEXA_PECCC;  C6DKD2, LEXA_PECCP;  
Q03FU3, LEXA_PEDPA;  Q3A3S5, LEXA_PELCD;  A5D2J8, LEXA_PELTS;  
Q4FM55, LEXA_PELUB;  Q187P1, LEXA_PEPD6;  A9BGA3, LEXA_PETMO;  
B4RBX6, LEXA_PHEZH;  Q7MZB8, LEXA_PHOLL;  Q6LVS1, LEXA_PHOPR;  
A1VNK0, LEXA_POLNA;  Q129C4, LEXA_POLSJ;  B4EYR3, LEXA_PROMH;  
Q07267, LEXA_PRORE;  Q15MZ2, LEXA_PSEA6;  A6V389, LEXA_PSEA7;  
B7UYS3, LEXA_PSEA8;  Q02PH1, LEXA_PSEAB;  P37452, LEXA_PSEAE;  
Q8KT78, LEXA_PSECL;  A4XSN5, LEXA_PSEMY;  P0A154, LEXA_PSEPU;  
A1SR67, LEXA_PSYIN;  Q1LLW6, LEXA_RALME;  B2UAG1, LEXA_RALPJ;  
Q8XZU1, LEXA_RALSO;  B3PYQ7, LEXA_RHIE6;  Q2K8X2, LEXA_RHIEC;  
Q1MH39, LEXA_RHIL3;  Q98MD2, LEXA_RHILO;  B5ZN98, LEXA_RHILW;  
Q92PW3, LEXA_RHIME;  P61605, LEXA_RHIRD;  P61613, LEXA_RHOCA;  
B6IST2, LEXA_RHOCS;  Q2IW99, LEXA_RHOP2;  Q07NH5, LEXA_RHOP5;  
P61614, LEXA_RHOPA;  Q215D1, LEXA_RHOPB;  Q136C2, LEXA_RHOPS;  
B3Q6P2, LEXA_RHOPT;  Q2RT47, LEXA_RHORT;  A3PHK4, LEXA_RHOS1;  
Q9ZFA4, LEXA_RHOS4;  A4WX64, LEXA_RHOS5;  Q163X5, LEXA_ROSDO;  
A5UQF5, LEXA_ROSS1;  Q5LRH4, LEXA_RUEPO;  Q1GHJ8, LEXA_RUEST;  
Q21JT2, LEXA_SACD2;  B5F1Q6, LEXA_SALA4;  A9MGP6, LEXA_SALAR;  
Q57GZ0, LEXA_SALCH;  B5FQR1, LEXA_SALDC;  B5QZ62, LEXA_SALEP;  
B5R7T6, LEXA_SALG2;  B4TDM0, LEXA_SALHS;  B4T1T2, LEXA_SALNS;  
Q5PL14, LEXA_SALPA;  A9N1L6, LEXA_SALPB;  C0Q514, LEXA_SALPC;  
B5BJW0, LEXA_SALPK;  B4TQQ5, LEXA_SALSV;  P0A274, LEXA_SALTI;  
P0A273, LEXA_SALTY;  A8GKB4, LEXA_SERP5;  A1SBC7, LEXA_SHEAM;  
B8ECL9, LEXA_SHEB2;  A3CYX7, LEXA_SHEB5;  A6WU05, LEXA_SHEB8;  
A9KUW8, LEXA_SHEB9;  Q12ID6, LEXA_SHEDO;  Q089E2, LEXA_SHEFN;  
B0TNT3, LEXA_SHEHH;  A3Q951, LEXA_SHELP;  Q8E8Q8, LEXA_SHEON;  
A8H9S0, LEXA_SHEPA;  A4YC04, LEXA_SHEPC;  B8CUX0, LEXA_SHEPW;  
A0L2D8, LEXA_SHESA;  A8FPP0, LEXA_SHESH;  Q0HDL5, LEXA_SHESM;  
Q0HPW6, LEXA_SHESR;  A1RE93, LEXA_SHESW;  B1KM68, LEXA_SHEWM;  
B2TX73, LEXA_SHIB3;  Q31TV1, LEXA_SHIBS;  Q327V0, LEXA_SHIDS;  
Q0SXR0, LEXA_SHIF8;  P0A7C5, LEXA_SHIFL;  Q3YUU1, LEXA_SHISS;  
A6U971, LEXA_SINMW;  Q2NR09, LEXA_SODGM;  A9F881, LEXA_SORC5;  
Q1GUX2, LEXA_SPHAL;  A5VB97, LEXA_SPHWW;  A7X1Z4, LEXA_STAA1;  
Q2FH94, LEXA_STAA3;  Q2FYU1, LEXA_STAA8;  Q2YXS8, LEXA_STAAB;  
Q9L4P1, LEXA_STAAC;  A6QGP1, LEXA_STAAE;  P65819, LEXA_STAAM;  
P65820, LEXA_STAAN;  Q6GH67, LEXA_STAAR;  Q6G9L9, LEXA_STAAS;  
Q93SM0, LEXA_STAAW;  B9DP69, LEXA_STACT;  Q5HPK2, LEXA_STAEQ;  
Q4L648, LEXA_STAHJ;  Q49XD4, LEXA_STAS1;  Q82KE0, LEXA_STRAW;  
O86847, LEXA_STRC2;  O69979, LEXA_STRCO;  B4SRA9, LEXA_STRM5;  
Q67NM2, LEXA_SYMTH;  A0LGS1, LEXA_SYNFM;  Q0AY82, LEXA_SYNWW;  
C5BIH2, LEXA_TERTT;  B7IDD1, LEXA_THEAB;  Q47MY4, LEXA_THEFY;  
A8F429, LEXA_THELT;  A6LM87, LEXA_THEM4;  O33927, LEXA_THEMA;  
O86948, LEXA_THENE;  B9K9N0, LEXA_THENN;  A5IN94, LEXA_THEP1;  
B1L838, LEXA_THESQ;  Q3SIT9, LEXA_THIDA;  C4L7X7, LEXA_TOLAT;  
C5CKV7, LEXA_VARPS;  A1WSJ3, LEXA_VEREI;  A5F4F6, LEXA_VIBC3;  
A7N0W6, LEXA_VIBCB;  Q9KVP9, LEXA_VIBCH;  C3LPT4, LEXA_VIBCM;  
Q5E209, LEXA_VIBF1;  B5FCB2, LEXA_VIBFM;  Q87KN2, LEXA_VIBPA;  
B7VM94, LEXA_VIBSL;  Q8DD47, LEXA_VIBVU;  Q7MQ85, LEXA_VIBVY;  
Q93MQ9, LEXA_XANCA;  P60512, LEXA_XANCI;  A7INJ8, LEXA_XANP2;  
B2I679, LEXA_XYLF2;  Q9PH24, LEXA_XYLFA;  B0U1K7, LEXA_XYLFM;  
Q87F45, LEXA_XYLFT;  A1JRT9, LEXA_YERE8;  A7FN96, LEXA_YERP3;  
Q1C0U1, LEXA_YERPA;  B2K1U7, LEXA_YERPB;  Q8ZJ16, LEXA_YERPE;  
A9R273, LEXA_YERPG;  Q1CE98, LEXA_YERPN;  A4TRU5, LEXA_YERPP;  
Q66FG7, LEXA_YERPS;  B1JNE3, LEXA_YERPY;  Q5NR31, LEXA_ZYMMO;  

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