ID   3.4.21.89
DE   Signal peptidase I.
AN   Bacterial leader peptidase I.
AN   Phage-procoat-leader peptidase.
AN   SPase I.
CA   Cleavage of hydrophobic, N-terminal signal or leader sequences from
CA   secreted and periplasmic proteins.
CC   -!- Unaffected by inhibitors of most serine peptidases, but site-directed
CC       mutagenesis implicates a Ser/Lys catalytic dyad in activity.
CC   -!- Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein,
CC       producing free signal peptide and coat protein.
CC   -!- Eukaryote signal peptidases that may have somewhat different
CC       specificity are known from the endoplasmic reticulum membrane and
CC       mitochondrial inner membrane.
CC   -!- Belongs to peptidase family S26.
CC   -!- Formerly EC 3.4.99.36.
PR   PROSITE; PDOC00418;
DR   P41026, LEP1_BACAM ;  P72660, LEP1_SYNY3 ;  P41025, LEP2_BACAM ;
DR   P73157, LEP2_SYNY3 ;  P37943, LEPP_BACNA ;  Q57350, LEPQ_BACNA ;
DR   P28628, LEPS_BACSU ;  P71013, LEPT_BACSU ;  P42959, LEPU_BACSU ;
DR   O07560, LEPV_BACSU ;  P54506, LEPW_BACSU ;  O67088, LEP_AQUAE  ;
DR   P41027, LEP_BACCL  ;  P42668, LEP_BACLI  ;  P57347, LEP_BUCAI  ;
DR   Q8K9R0, LEP_BUCAP  ;  Q89AM6, LEP_BUCBP  ;  P00803, LEP_ECOLI  ;
DR   P44454, LEP_HAEIN  ;  Q9ZLQ5, LEP_HELPJ  ;  O25300, LEP_HELPY  ;
DR   O33021, LEP_MYCLE  ;  Q10789, LEP_MYCTU  ;  Q51876, LEP_PHOLA  ;
DR   Q9I5G7, LEP_PSEAE  ;  P26844, LEP_PSEFL  ;  A8GM78, LEP_RICAH  ;
DR   A8GYE1, LEP_RICB8  ;  Q1RHA1, LEP_RICBR  ;  A8EXI2, LEP_RICCK  ;
DR   Q92JB1, LEP_RICCN  ;  Q4UKA7, LEP_RICFE  ;  A8F0M1, LEP_RICM5  ;
DR   Q9ZE32, LEP_RICPR  ;  A8GQT7, LEP_RICRS  ;  Q8L2J7, LEP_RICTY  ;
DR   P0A1W3, LEP_SALTI  ;  P0A1W2, LEP_SALTY  ;  Q5HHB9, LEP_STAAC  ;
DR   P0A067, LEP_STAAM  ;  P0A068, LEP_STAAN  ;  Q6GIC3, LEP_STAAR  ;
DR   Q6GAW1, LEP_STAAS  ;  P0A070, LEP_STAAU  ;  P0A069, LEP_STAAW  ;
DR   O07344, LEP_STRPN  ;  P59662, LEP_STRR6  ;  Q8H0W1, PLSP1_ARATH;
DR   P67810, SC11A_BOVIN;  P67811, SC11A_CANFA;  P67812, SC11A_HUMAN;
DR   Q9R0P6, SC11A_MOUSE;  Q5R9C7, SC11A_PONAB;  P42667, SC11A_RAT  ;
DR   P0C7V7, SC11B_HUMAN;  P13679, SC11C_CANFA;  Q9BY50, SC11C_HUMAN;
DR   Q9D8V7, SC11C_MOUSE;  Q5RC30, SC11C_PONAB;  Q9WTR7, SC11C_RAT  ;
DR   F0UDD2, SEC11_AJEC8;  C0NKT8, SEC11_AJECG;  C6HB29, SEC11_AJECH;
DR   A6QX24, SEC11_AJECN;  C5G8L5, SEC11_AJEDR;  C5JJG5, SEC11_AJEDS;
DR   D4ALL0, SEC11_ARTBC;  E4V4X0, SEC11_ARTGP;  C5FQ45, SEC11_ARTOC;
DR   Q759W4, SEC11_ASHGO;  A1CL29, SEC11_ASPCL;  B0XWT3, SEC11_ASPFC;
DR   Q4WYF4, SEC11_ASPFU;  Q2UBW3, SEC11_ASPOR;  Q0CQC5, SEC11_ASPTN;
DR   Q5A869, SEC11_CANAL;  C4YNJ0, SEC11_CANAW;  B9WKT4, SEC11_CANDC;
DR   C5M4J6, SEC11_CANTT;  Q2H1P3, SEC11_CHAGB;  C4Y3D4, SEC11_CLAL4;
DR   C5PA33, SEC11_COCP7;  E9CXH2, SEC11_COCPS;  E3QXY4, SEC11_COLGM;
DR   Q6BP15, SEC11_DEBHA;  Q86JD4, SEC11_DICDI;  Q5B8K4, SEC11_EMENI;
DR   F0XJH4, SEC11_GROCL;  Q6CMR5, SEC11_KLULA;  B0D4L0, SEC11_LACBS;
DR   C5DDH1, SEC11_LACTC;  E5A8D2, SEC11_LEPMJ;  A5DS09, SEC11_LODEL;
DR   A4RGA1, SEC11_MAGO7;  E9E796, SEC11_METAQ;  E9F8V9, SEC11_METAR;
DR   C7ZHK5, SEC11_NECH7;  A1D6D8, SEC11_NEOFI;  Q7RY44, SEC11_NEUCR;
DR   C1GU90, SEC11_PARBA;  C1FYD2, SEC11_PARBD;  C0S3S0, SEC11_PARBP;
DR   B6HC89, SEC11_PENCW;  B6Q5G0, SEC11_PENMQ;  E7R7C4, SEC11_PICAD;
DR   A5DIZ8, SEC11_PICGU;  C4QXP7, SEC11_PICPG;  A3LXS1, SEC11_PICST;
DR   B2B3T2, SEC11_PODAN;  B2WEL2, SEC11_PYRTR;  E3RR70, SEC11_PYRTT;
DR   D8Q7Q5, SEC11_SCHCM;  O74323, SEC11_SCHPO;  A7E716, SEC11_SCLS1;
DR   B8M5K5, SEC11_TALSN;  D4D5I1, SEC11_TRIVH;  D5GNC3, SEC11_TUBMM;
DR   C4JYM4, SEC11_UNCRE;  C9S8G0, SEC11_VERA1;  Q6CAG9, SEC11_YARLI;
DR   B3LTI7, SEC11_YEAS1;  C7GLT4, SEC11_YEAS2;  A6ZVU2, SEC11_YEAS7;
DR   C8ZAS4, SEC11_YEAS8;  E7KDY6, SEC11_YEASA;  E7Q587, SEC11_YEASB;
DR   E7KQ01, SEC11_YEASL;  P15367, SEC11_YEAST;  E7LVX4, SEC11_YEASV;
DR   E7QG89, SEC11_YEASZ;  C5E3W1, SEC11_ZYGRC;  O04348, TPP1_ARATH ;
DR   Q9M9Z2, TPP2_ARATH ;
//