ENZYME

ENZYME entry: EC 3.4.21.93

Accepted Name

Proprotein convertase 1.

Alternative Name(s)

NEC 1.

Neuroendocrine convertase 1.

PC1.

Prohormone convertase I.

Reaction catalysed

Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds

Comment(s)

A calcium dependent enzyme, maximally active at about pH 5.5.
Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin.
Unlike prohormone convertase 2, does not cleave proluteinizing- hormone-releasing hormone.
Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 2.
Belongs to peptidase family S8.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature