ID   3.4.21.93
DE   proprotein convertase 1.
AN   NEC 1.
AN   neuroendocrine convertase 1.
AN   PC1.
AN   prohormone convertase I.
CA   Release of protein hormones, neuropeptides and renin from their
CA   precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
CC   -!- A calcium dependent enzyme, maximally active at about pH 5.5.
CC   -!- Substrates include pro-opiomelanocortin, prorenin, proenkephalin,
CC       prodynorphin, prosomatostatin and proinsulin.
CC   -!- Unlike prohormone convertase 2, does not cleave proluteinizing-
CC       hormone-releasing hormone.
CC   -!- Usually processing of prodynorphin occurs at a bond in which P2 is
CC       Thr.
CC   -!- Present in the regulated secretory pathway of neuroendocrine cells,
CC       commonly actin co-operatively with prohormone convertase 2.
CC   -!- Belongs to peptidase family S8.
DR   Q9GLR1, NEC1_BOVIN ;  P29120, NEC1_HUMAN ;  P63239, NEC1_MOUSE ;
DR   P63240, NEC1_MUSCO ;  P28840, NEC1_RAT   ;
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