ENZYME entry: EC 3.4.22.15
| Accepted Name |
|---|
| Cathepsin L.
|
| Reaction catalysed |
|---|
| Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity |
| Comment(s) |
|---|
- A lysosomal enzyme that is readily inhibited by the diazomethane
inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64.
- Belongs to peptidase family C1.
|
| Cross-references |
|---|
| PROSITE | PDOC00126 |
| BRENDA | 3.4.22.15 |
| EC2PDB | 3.4.22.15 |
| ExplorEnz | 3.4.22.15 |
| PRIAM enzyme-specific profiles | 3.4.22.15 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.15 |
| IUBMB Enzyme Nomenclature | 3.4.22.15 |
| IntEnz | 3.4.22.15 |
| MEDLINE | Find literature relating to 3.4.22.15 |
| MetaCyc | 3.4.22.15 |
| UniProtKB/Swiss-Prot |
| P25975, CATL1_BOVIN; | Q9GL24, CATL1_CANFA; | P09648, CATL1_CHICK; |
| Q9GKL8, CATL1_CHLAE; | Q09093, CATL1_FASHE; | P25773, CATL1_FELCA; |
| P07711, CATL1_HUMAN; | P06797, CATL1_MOUSE; | Q94714, CATL1_PARTE; |
| Q28944, CATL1_PIG; | P07154, CATL1_RAT; | Q10991, CATL1_SHEEP; |
| P80342, CATL2_FASHE; | A0E358, CATL2_PARTE; | P80532, CATL3_FASHE; |
| Q94715, CATL3_PARTE; | O17473, CATL_BRUPA; | Q95029, CATL_DROME; |
| Q26636, CATL_SARPE; | Q26534, CATL_SCHMA; |
|
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