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ENZYME entry: EC 3.4.22.15

Accepted Name
Cathepsin L.
Reaction catalysed
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Comment(s)
  • A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64.
  • Belongs to peptidase family C1.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.15
EC2PDB3.4.22.15
ExplorEnz3.4.22.15
PRIAM enzyme-specific profiles3.4.22.15
KEGG Ligand Database for Enzyme Nomenclature3.4.22.15
IUBMB Enzyme Nomenclature3.4.22.15
IntEnz3.4.22.15
MEDLINEFind literature relating to 3.4.22.15
MetaCyc3.4.22.15
UniProtKB/Swiss-Prot
P25975, CATL1_BOVIN;  Q9GL24, CATL1_CANFA;  P09648, CATL1_CHICK;  
Q9GKL8, CATL1_CHLAE;  Q09093, CATL1_FASHE;  P25773, CATL1_FELCA;  
P07711, CATL1_HUMAN;  P06797, CATL1_MOUSE;  Q94714, CATL1_PARTE;  
Q28944, CATL1_PIG;  P07154, CATL1_RAT;  Q10991, CATL1_SHEEP;  
P80342, CATL2_FASHE;  A0E358, CATL2_PARTE;  P80532, CATL3_FASHE;  
Q94715, CATL3_PARTE;  O17473, CATL_BRUPA;  Q95029, CATL_DROME;  
Q26636, CATL_SARPE;  Q26534, CATL_SCHMA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
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