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ENZYME entry: EC 3.4.22.28

Accepted Name
Picornain 3C.
Alternative Name(s)
Foot-and-mouth protease 3C.
Picornavirus endopeptidase 3C.
Poliovirus protease 3C.
Rhinovirus protease 3C.
Reaction catalysed
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Comment(s)
  • From entero-, rhino-, aphto- and cardioviruses.
  • Larger than the homologous virus picornain 2A.
  • Belongs to peptidase family C3.
Cross-references
BRENDA3.4.22.28
EC2PDB3.4.22.28
ExplorEnz3.4.22.28
PRIAM enzyme-specific profiles3.4.22.28
KEGG Ligand Database for Enzyme Nomenclature3.4.22.28
IUBMB Enzyme Nomenclature3.4.22.28
IntEnz3.4.22.28
MEDLINEFind literature relating to 3.4.22.28
MetaCyc3.4.22.28
UniProtKB/Swiss-Prot
Q9YLS4, POLG_AEVCA;  Q6WQ42, POLG_AEVL2;  Q6R325, POLG_AEVVR;  
P12915, POLG_BOVEV;  Q65900, POLG_CX16G;  Q9QF31, POLG_CX16T;  
P22055, POLG_CXA21;  P36290, POLG_CXA24;  P21404, POLG_CXA9;  
P08291, POLG_CXB1J;  Q9YLG5, POLG_CXB2O;  P03313, POLG_CXB3N;  
Q66282, POLG_CXB3W;  Q86887, POLG_CXB4E;  P08292, POLG_CXB4J;  
Q03053, POLG_CXB5P;  Q9QL88, POLG_CXB6S;  O91734, POLG_EC01F;  
Q9YLJ1, POLG_EC05N;  Q66474, POLG_EC06C;  Q66577, POLG_EC09B;  
Q66849, POLG_EC09H;  P29813, POLG_EC11G;  Q66575, POLG_EC12T;  
Q9WN78, POLG_EC30B;  P08490, POLG_ECHO9;  P03304, POLG_EMCV;  
P17593, POLG_EMCVB;  P17594, POLG_EMCVD;  Q66765, POLG_EMCVR;  
P12296, POLG_ENMGO;  P03306, POLG_FMDV1;  P03307, POLG_FMDV5;  
P03308, POLG_FMDVA;  P03309, POLG_FMDVC;  P03310, POLG_FMDVI;  
P03305, POLG_FMDVO;  P03311, POLG_FMDVS;  P49303, POLG_FMDVZ;  
Q8V0N6, POLG_HAV88;  Q5Y944, POLG_HAVCF;  Q67825, POLG_HAVGB;  
A3FMB2, POLG_HAVH2;  Q05794, POLG_HAVHA;  P08617, POLG_HAVHM;  
A5LGW7, POLG_HAVJ8;  P06441, POLG_HAVLA;  P13901, POLG_HAVMB;  
Q9DWR1, POLG_HAVNO;  P14553, POLG_HAVS2;  P32537, POLG_HE701;  
Q66478, POLG_HE71B;  Q66479, POLG_HE71M;  Q66578, POLG_HPE1H;  
Q9YID8, POLG_HPE23;  O73556, POLG_HPE2W;  P03303, POLG_HRV14;  
Q82122, POLG_HRV16;  P23008, POLG_HRV1A;  P12916, POLG_HRV1B;  
P04936, POLG_HRV2;  Q82081, POLG_HRV3;  P07210, POLG_HRV8A;  
O41174, POLG_PEV9U;  P03300, POLG_POL1M;  P03301, POLG_POL1S;  
P06210, POLG_POL2L;  P23069, POLG_POL2W;  P06209, POLG_POL32;  
P03302, POLG_POL3L;  P16604, POLG_SVDVH;  P13900, POLG_SVDVU;  
P08544, POLG_TMEVB;  P13899, POLG_TMEVD;  P08545, POLG_TMEVG;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
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