ENZYME entry: EC 3.4.22.32

Accepted Name
Stem bromelain.
Alternative Name(s)
Bromelain.
Reaction catalysed
Broad specificity for cleavage of proteins, but strong preference for Z-Arg-Arg-|-NHMec among small molecule substrates
Comment(s)
  • The most abundant of cysteine endopeptidases of the stem of the pineapple plant, Ananas comosus.
  • Distinct from the bromelain found in the pineapple fruit (EC 3.4.22.33).
  • Scarcely inhibited by chicken cystatin and also very slowly inactivated by E-64.
  • Belongs to peptidase family C1.
  • Formerly EC 3.4.4.24 and EC 3.4.22.4.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.32
EC2PDB3.4.22.32
ExplorEnz3.4.22.32
PRIAM enzyme-specific profiles3.4.22.32
KEGG Ligand Database for Enzyme Nomenclature3.4.22.32
IUBMB Enzyme Nomenclature3.4.22.32
IntEnz3.4.22.32
MEDLINEFind literature relating to 3.4.22.32
MetaCyc3.4.22.32
UniProtKB/Swiss-Prot
P14518, BROM2_ANACO

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