ENZYME entry: EC 3.4.22.33

Accepted Name
Fruit bromelain.
Reaction catalysed
Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg-|-NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-|-NHMec (c.f. stem bromelain)
Comment(s)
  • From the pineapple plant, Ananas comosus.
  • Scarcely inhibited by chicken cystatin.
  • Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain (formerly EC 3.4.99.18), is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin.
  • Belongs to peptidase family C1.
  • Formerly EC 3.4.4.24, EC 3.4.22.4 and EC 3.4.22.5.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.33
EC2PDB3.4.22.33
ExplorEnz3.4.22.33
PRIAM enzyme-specific profiles3.4.22.33
KEGG Ligand Database for Enzyme Nomenclature3.4.22.33
IUBMB Enzyme Nomenclature3.4.22.33
IntEnz3.4.22.33
MEDLINEFind literature relating to 3.4.22.33
MetaCyc3.4.22.33
UniProtKB/Swiss-Prot
O23791, BROM1_ANACO

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