ENZYME entry: EC 3.4.22.34

Accepted Name
Legumain.
Alternative Name(s)
Asparaginyl endopeptidase.
Bean endopeptidase.
Hemoglobinase.
Phaseolin.
Vicilin peptidohydrolase.
Reaction catalysed
Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa-bonds
Comment(s)
  • Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes.
  • Not inhibited by compound E-64.
  • Belongs to peptidase family C13.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.34
EC2PDB3.4.22.34
ExplorEnz3.4.22.34
PRIAM enzyme-specific profiles3.4.22.34
KEGG Ligand Database for Enzyme Nomenclature3.4.22.34
IUBMB Enzyme Nomenclature3.4.22.34
IntEnz3.4.22.34
MEDLINEFind literature relating to 3.4.22.34
MetaCyc3.4.22.34
UniProtKB/Swiss-Prot
P80527, HGLB1_FASHE;  P80530, HGLB2_FASHE;  P42665, HGLB_SCHJA;  
P09841, HGLB_SCHMA;  P49046, LEGU_CANEN;  Q95M12, LGMN_BOVIN;  
Q99538, LGMN_HUMAN;  Q4R4T8, LGMN_MACFA;  O89017, LGMN_MOUSE;  
Q5R5D9, LGMN_PONAB;  Q9R0J8, LGMN_RAT;  

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