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ENZYME entry: EC

Accepted Name
Alternative Name(s)
Interleukin 1-beta converting enzyme.
Interleukin 1-beta-converting endopeptidase.
Interleukin-1 beta convertase precursor.
Interleukin-1-beta convertase.
Pro-interleukin 1-beta proteinase.
Prointerleukin 1-beta protease.
Reaction catalysed
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-
  • Part of the family of inflammatory-caspases, which also includes caspase-4 (EC and caspase-5 (EC in humans and caspase-11 (EC, caspase-12, caspase-13 and caspase-14 in mice.
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation.
  • Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.
  • Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
  • Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans.
  • Belongs to peptidase family C14.
PRIAM enzyme-specific profiles3.4.22.36
KEGG Ligand Database for Enzyme Nomenclature3.4.22.36
IUBMB Enzyme Nomenclature3.4.22.36
MEDLINEFind literature relating to
P55865, CAS1A_XENLA;  P55867, CAS1B_XENLA;  Q9MZV7, CASP1_CANLF;  
P29452, CASP1_MOUSE;  Q9N2I1, CASP1_PIG;  P43527, CASP1_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
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