ID   3.4.22.36
DE   caspase-1.
AN   interleukin-1beta convertase.
AN   interleukin-1 beta convertase precursor.
AN   interleukin 1beta-converting endopeptidase.
AN   interleukin 1beta converting enzyme.
AN   prointerleukin 1beta protease.
AN   pro-interleukin 1beta proteinase.
CA   Strict requirement for an Asp residue at position P1 and has a preferred
CA   cleavage sequence of Tyr-Val-Ala-Asp-|-.
CC   -!- Part of the family of inflammatory-caspases, which also includes
CC       caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and
CC       caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in
CC       mice.
CC   -!- Contains a caspase-recruitment domain (CARD) in its N-terminal
CC       prodomain, which plays a role in procaspase activation.
CC   -!- Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta,
CC       a potent mediator of inflammation.
CC   -!- Also activates the proinflammatory cytokine, IL-18, which is also
CC       known as interferon-gamma-inducing factor.
CC   -!- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
CC   -!- Caspase-11 plays a critical role in the activation of caspase-1 in
CC       mice whereas caspase-4 enhances its activation in humans.
CC   -!- Belongs to peptidase family C14.
DR   P55865, CAS1A_XENLA;  P55867, CAS1B_XENLA;  Q9MZV7, CASP1_CANLF;
DR   Q9MZV6, CASP1_FELCA;  Q9TV13, CASP1_HORSE;  P29466, CASP1_HUMAN;
DR   P29452, CASP1_MOUSE;  Q9N2I1, CASP1_PIG  ;  P43527, CASP1_RAT  ;
DR   Q9I9L7, CASPA_DANRE;  G5EBM1, CSP1_CAEEL ;
//