ENZYME entry: EC 220.127.116.11
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|Potyvirus NIa protease.|
|Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved|
- The potyviruses cause diseases in plants, and inclusion bodies appear
in the host cell nuclei, protein a of these being the endopeptidase.
- The enzyme finds practical use when encoded in vectors for the
artificial expression of recombinant fusion proteins, since it can
confer on them the capacity for autolytic cleavage.
- It is also reported that transgenic plants expressing the enzyme are
resistant to viral infection.
- Belongs to peptidase family C4.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|P90245, POL1_BAMMN; ||Q04574, POL1_BAYMG; ||Q01206, POL1_BAYMJ; |
|Q9YJW3, POL1_BAYMY; ||Q65399, POLG_BCMNN; ||Q65730, POLG_BSTV1; |
|Q65729, POLG_BSTVG; ||Q6XW15, POLG_BTMV; ||A0AUJ5, POLG_BVY3; |
|P17765, POLG_BYMV; ||P31999, POLG_LMV0; ||P89876, POLG_LMVE; |
|P20234, POLG_OMV; ||Q01500, POLG_PEMVC; ||O56075, POLG_PEMVM; |
|P13529, POLG_PPVD; ||Q01681, POLG_PPVEA; ||P17766, POLG_PPVNA; |
|P17767, POLG_PPVRA; ||Q84934, POLG_PPVSK; ||Q01901, POLG_PRSVH; |
|P29152, POLG_PSBMV; ||Q85197, POLG_PVMA; ||Q02963, POLG_PVYHU; |
|P18247, POLG_PVYN; ||O11436, POLG_RGMVD; ||Q90069, POLG_SBMVG; |
|P21231, POLG_SBMVN; ||P89201, POLG_SPMMV; ||P04517, POLG_TEV; |
|A4KZ49, POLG_TRMVU; ||P89509, POLG_TUMVJ; ||Q02597, POLG_TUMVQ; |
|P09814, POLG_TVMV; ||P18478, POLG_WMV2U; ||P18479, POLG_ZYMVC; |
|Q89330, POLG_ZYMVR; ||O36979, POLG_ZYMVS; |
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