ENZYME entry: EC 3.4.22.45

Accepted Name
Helper-component proteinase.
Alternative Name(s)
HC-Pro.
Reaction catalysed
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein
Comment(s)
  • Known from many potyviruses.
  • The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities.
  • The N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity.
  • Belongs to peptidase family C6.
Cross-references
BRENDA3.4.22.45
EC2PDB3.4.22.45
ExplorEnz3.4.22.45
PRIAM enzyme-specific profiles3.4.22.45
KEGG Ligand Database for Enzyme Nomenclature3.4.22.45
IUBMB Enzyme Nomenclature3.4.22.45
IntEnz3.4.22.45
MEDLINEFind literature relating to 3.4.22.45
MetaCyc3.4.22.45
UniProtKB/Swiss-Prot
Q65329, POL2_BAMMA;  P89684, POL2_BAMMN;  Q65657, POL2_BAMMU;  
Q01365, POL2_BAYMG;  Q01207, POL2_BAYMJ;  Q9YJW2, POL2_BAYMY;  
Q65399, POLG_BCMNN;  Q65730, POLG_BSTV1;  Q6XW15, POLG_BTMV;  
A0AUJ5, POLG_BVY3;  P17765, POLG_BYMV;  P89876, POLG_LMV0;  
P31999, POLG_LMVE;  Q01500, POLG_PEMVC;  O56075, POLG_PEMVM;  
P13529, POLG_PPVD;  P17766, POLG_PPVNA;  P17767, POLG_PPVRA;  
Q84934, POLG_PPVSK;  Q01901, POLG_PRSVH;  P29152, POLG_PSBMV;  
Q85197, POLG_PVMA;  P22601, POLG_PVYC;  Q02963, POLG_PVYHU;  
P18247, POLG_PVYN;  P22602, POLG_PVYO;  O11436, POLG_RGMVD;  
Q90069, POLG_SBMVG;  P21231, POLG_SBMVN;  P89201, POLG_SPMMV;  
P04517, POLG_TEV;  A4KZ49, POLG_TRIMV;  P89509, POLG_TUMVJ;  
Q02597, POLG_TUMVQ;  P09814, POLG_TVMV;  P18479, POLG_ZYMVC;  
Q89330, POLG_ZYMVR;  O36979, POLG_ZYMVS;  

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