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ENZYME entry: EC 126.96.36.199
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|All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage|
- In both Saccharomyces cerevisiae and human cells, cleavage of the
cohesin subunit Scc1 by separase is required for sister chromatid
separation in mitosis.
- S.cerevisiae separase is also known to cleave the Rec8 subunit of a
meiotic cohesin complex and the kinetochore protein Slk19.
- Belongs to peptidase family C50.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
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entries corresponding to 3.4.22.-
entries corresponding to 3.4.-.-
entries corresponding to 3.-.-.-