ENZYME entry: EC 3.4.22.52

Accepted Name
Calpain-1.
Alternative Name(s)
Calcium-activated neutral protease I.
Mu-calpain.
Reaction catalysed
Broad endopeptidase specificity
Cofactor(s)
Ca(2+).
Comment(s)
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.52
EC2PDB3.4.22.52
ExplorEnz3.4.22.52
PRIAM enzyme-specific profiles3.4.22.52
KEGG Ligand Database for Enzyme Nomenclature3.4.22.52
IUBMB Enzyme Nomenclature3.4.22.52
IntEnz3.4.22.52
MEDLINEFind literature relating to 3.4.22.52
MetaCyc3.4.22.52
UniProtKB/Swiss-Prot
Q27970, CAN1_BOVIN;  P07384, CAN1_HUMAN;  Q9GLG2, CAN1_MACFA;  
O35350, CAN1_MOUSE;  P35750, CAN1_PIG;  Q5NVS7, CAN1_PONAB;  
P06815, CAN1_RABIT;  P97571, CAN1_RAT;  P00789, CANX_CHICK;  

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