ID   3.4.22.54
DE   Calpain-3.
AN   Calcium-activated neutral proteinase 3.
AN   Calpain L3.
AN   Calpain p94.
AN   CANP 3.
AN   CAPN3.
AN   Muscle-specific calcium-activated neutral protease 3.
CA   Broad endopeptidase activity.
CF   Calcium.
CC   -!- Activated by autoproteolytic cleavage of insertion sequence 1 (IS1),
CC       which allows substrates and inhibitors gain access to the active
CC       site.
CC   -!- Substrates include the protein itself and connectin/titin.
CC   -!- Belongs to peptidase family C2.
PR   PROSITE; PDOC00126;
PR   PROSITE; PDOC50203;
DR   P51186, CAN3_BOVIN ;  Q92177, CAN3_CHICK ;  P20807, CAN3_HUMAN ;
DR   Q9GLG7, CAN3_MACFA ;  Q64691, CAN3_MOUSE ;  P43368, CAN3_PIG   ;
DR   P16259, CAN3_RAT   ;  Q9TTH8, CAN3_SHEEP ;
//