ID 3.4.22.57 DE caspase-4. AN CASP-4. AN ICErelII. AN ICErel-II. AN Ich-2. CA Strict requirement for Asp at the P1 position. It has a preferred CA cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val- CA Asp-|-. CC -!- Part of the family of inflammatory-caspases, which also includes CC caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and CC caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in CC mice. CC -!- Contains a caspase-recruitment domain (CARD) in its N-terminal CC prodomain, which plays a role in procaspase activation. CC -!- Able to cleave itself and the p30 caspase-1 precursor, but, unlike CC caspase-1, it is very inefficient at generating mature interleukin- CC 1beta (IL-1beta) from pro-IL-1beta. CC -!- Both this enzyme and caspase-5 can cleave pro-caspase-3 to release CC the small subunit (p12) but not the large subunit (p17). CC -!- The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this CC enzyme, but more slowly. CC -!- Belongs to peptidase family C14. DR Q5E9C1, CASP4_BOVIN; P49662, CASP4_HUMAN; //